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SML2907

Sigma-Aldrich

Azumolene

≥98% (HPLC)

Synonym(s):

1-[[[5-(4-Bromophenyl)-2-oxazolyl]methylene]amino]-2,4-imidazolidinedione, EU 4093

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5 MG
£83.40
25 MG
£270.00

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5 MG
£83.40
25 MG
£270.00

About This Item

Empirical Formula (Hill Notation):
C13H9BrN4O3
CAS Number:
64748-79-4
Molecular Weight:
349.14
MDL number:
MFCD00867710
UNSPSC Code:
12352200
NACRES:
NA.77

£83.40

Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to very dark gray

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

InChI

1S/C13H9BrN4O3/c14-9-3-1-8(2-4-9)10-5-15-12(21-10)6-16-18-7-11(19)17-13(18)20/h1-6H,7H2,(H,17,19,20)

InChI key

SEGCNGONCZQFDW-UHFFFAOYSA-N

Biochem/physiol Actions

Azumolene, a more water-soluble analog of dantrolene, is a potent inhibitor of sarcoplasmic reticulum (SR) ryanodine receptor (RyR) that inhibits skeletal muscle SR Ca2+ release. Azumolene is a direct acting skeletal muscle relaxant that induces effective blockade of skeletal muscle RyR1.
potent inhibitor of sarcoplasmic reticulum ryanodine receptor

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000166770
0000166772

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Erin E Talbert et al.
PloS one, 11(2), e0148161-e0148161 (2016-02-06)
Mechanical ventilation (MV) is a life-saving intervention for patients in respiratory failure. However, prolonged MV causes the rapid development of diaphragm muscle atrophy, and diaphragmatic weakness may contribute to difficult weaning from MV. Therefore, developing a therapeutic countermeasure to protect
Daoyuan Si et al.
Journal of cardiovascular electrophysiology, 29(12), 1707-1715 (2018-09-12)
Following long-duration ventricular fibrillation (LDVF), reinitiation of ventricular fibrillation (VF) poses a major challenge during resuscitation. Ryanodine receptor 2 (RyR2) becomes dysfunctional following VF. The relationship between LDVF, RyR2 modulation, and ventricular refibrillation, as well as the role of RyR2 phosphorylation
Yingfan Zhang et al.
The Journal of pharmacology and experimental therapeutics, 314(1), 94-102 (2005-04-16)
Azumolene is an analog of dantrolene, the only approved medicine for treatment of malignant hyperthermia (MH). The pharmacological mechanism of these drugs is to inhibit skeletal muscle sarcoplasmic reticulum (SR) Ca2+ release by modulating the activity of the SR ryanodine

Questions

  1. Do you have any clinical administration data in mailignant hyperthermia?

    1 answer

    1. This product is intended for laboratory research use only. Therefore, no clinical trial or other therapeutic information is available.

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