SML2739
SM1-71-R
≥98% (HPLC)
Synonym(s):
N-[2-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]propanamide
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About This Item
Empirical Formula (Hill Notation):
C24H28ClN7O
CAS Number:
Molecular Weight:
465.98
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
SM1-71-R, a reversible analog of multi-targeted kinase covalent inhibitor SM1-71, is a cell penetrant and potent multi-targeted kinase inhibitor. SM1-71-R can be used as a washout control to distinguish between covalent and non-covalent inhibition.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Li Tan et al.
Bioorganic & medicinal chemistry, 25(3), 838-846 (2016-12-25)
TAK1 (transforming growth factor-β-activated kinase 1) is an essential intracellular mediator of cytokine and growth factor signaling and a potential therapeutic target for the treatment of immune diseases and cancer. Herein we report development of a series of 2,4-disubstituted pyrimidine
Suman Rao et al.
The Journal of biological chemistry, 294(21), 8664-8673 (2019-03-13)
Most cancer cells are dependent on a network of deregulated signaling pathways for survival and are insensitive, or rapidly evolve resistance, to selective inhibitors aimed at a single target. For these reasons, drugs that target more than one protein (polypharmacology)
Suman Rao et al.
Cell chemical biology, 26(6), 818-829 (2019-04-16)
Covalent kinase inhibitors, which typically target cysteine residues, represent an important class of clinically relevant compounds. Approximately 215 kinases are known to have potentially targetable cysteines distributed across 18 spatially distinct locations proximal to the ATP-binding pocket. However, only 40
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