SML0637

BD750

≥98% (HPLC)

• Synonym(s): 2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol
• Empirical Formula (Hill Notation): C₁₄H₁₃N₃OS
• CAS Number: 892686-59-8
• Molecular Weight: 271.34
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 10 mg/mL, clear (warmed)
• storage temp.: 2-8°C

Description

Biochem/physiol Actions

BD750 is a benzothiazole derivative that inhibits proliferation of T-cells by a mechanism that involves inhibition of STAT5 phosphorylation and expression of cyclin D3 and CDK6. In the presence of BD750, human and mouse T cells stimulated with anti-CD3/CD28, alloantigen, PMA or ConA undergo G0/G1 cell cycle arrest, but express CD25 and CD69 and secrete IL-2 and IL-4. BD750 inhibits delayed-type hypersensitivity in mice.

BD750 is a benzothiazole deriviative, JAK3/STAT5 pathway inhibitor; immunosuppressnt and T-cell proliferation inhibitor.

Features and Benefits

This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable