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Key Documents

SAB1307178

Sigma-Aldrich

ANTI-GSDMA(N-TERMINAL) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

GSDM, GSDM1, GSDMA, Gasdermin-1, Gasdermin-A

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400 μL
£341.00

£341.00

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400 μL
£341.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

£341.00

Please contact Customer Service for Availability

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

49365 Da

species reactivity

mouse, human

technique(s)

flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000

NCBI accession no.

NP_835465.2

UniProt accession no.

Q96QA5

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GSDMA(284110)

General description

Gasdermin A (GSDMA) is located at 17q21.1 on the human chromosome. Its molecular weight is 49 kDa. GSDMA is localized in the pit cells of the gastric epithelium.

Biochem/physiol Actions

Gasdermin A (GSDMA) plays a major role in regulating the tumor growth factor- β (TGF-β) and induces apoptosis. Mutation in this gene leads to gastric adenocarcinoma.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SA100706AF

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GSDMA (gasdermin A)
Saeki N and Sasaki H
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2011)
Yingwei Zhu et al.
Cellular and molecular gastroenterology and hepatology, 12(2), 653-664 (2021-04-25)
Nonalcoholic steatohepatitis (NASH) is an inflammatory disease with severe outcomes. Hepatocyte death, including apoptosis, necrosis, and pyroptosis, has been implicated in pathophysiology of NASH. Pyroptosis is mediated by inflammasome activation pathways including caspase-1-mediated canonical signaling pathway and caspase-11-mediated noncanonical signaling

Questions

  1. Hello, what is the Immunogen range of this antibody?

    1 answer

    1. This GSDMA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human GSDMA.
      According to the target sequence description and sequence provided on Uniprot, the sequence should be :
      PGSSPSDPTDTGNFGFKNMLDTRVEGDVD

      ???????https://www.uniprot.org/uniprotkb/Q96QA5/entry

      Helpful?

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