S198
N6-p-Sulfophenyladenosine sodium salt
solid
Synonym(s):
4-[(9-β-D-Ribofuranosyl-9H-purin-6-yl)amino]-benzenesulfonic acid sodium-potassium salt, SPA
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About This Item
Empirical Formula (Hill Notation):
C16H16N5O7S · Na
Molecular Weight:
445.38
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77
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form
solid
color
off-white
solubility
DMSO: soluble
H2O: soluble
storage temp.
−20°C
Biochem/physiol Actions
A1 adenosine receptor agonist.
Caution
Hygroscopic. Photosensitive
Legal Information
Sold under license from the National Institutes of Health.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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K A Jacobson et al.
Journal of medicinal chemistry, 35(22), 4143-4149 (1992-10-30)
A series of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine was synthesized, revealing that N6-(p-sulfophenyl)adenosine (10b) is a moderately potent (Ki vs [3H]PIA in rat cortical membranes was 74nM) and A1-selective (120-fold) adenosine agonist, of exceptional aqueous solubility of > 1.5
E A van Schaick et al.
The Journal of pharmacology and experimental therapeutics, 287(1), 21-30 (1998-10-09)
Studies were designed to investigate differences in pharmacokinetics and pharmacodynamics of the adenosine A1 receptor agonist N6-(p-sulfophenyl)adenosine (SPA) between lean and obese Zucker rats. In conscious rats, time courses of the effect on heart rate and parameters of lipid metabolism
Haley S Province et al.
PloS one, 15(12), e0243986-e0243986 (2020-12-17)
Extracellular adenosine, a danger signal, can cause hypothermia. We generated mice lacking neuronal adenosine A1 receptors (A1AR, encoded by the Adora1 gene) to examine the contribution of these receptors to hypothermia. Intracerebroventricular injection of the selective A1AR agonist (Cl-ENBA, 5'-chloro-5'-deoxy-N6-endo-norbornyladenosine)
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