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O9764

Sigma-Aldrich

Anti-OTUB1 (57-70) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-HSPC263, Anti-OTB1, Anti-OTU1, Anti-Otubain 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~31 kDa

species reactivity

human

technique(s)

western blot: 1:500-1:2,000

UniProt accession no.

Q96FW1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... OTUB1(55611)

General description

OTUB1 (OTU domain-containing ubiquitin aldehyde binding protein 1), a deubiquitinating enzyme (DUB) is a member of the ovarian tumor (OTU) domain protease superfamily. It is expressed in kidney, intestine, brain, liver and lung. This gene is located on human chromosome 11q13.1.

Immunogen

synthetic peptide corresponding to amino acids 57-70 of human OTUB1

Application

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

OTUB1 (OTU domain-containing ubiquitin aldehyde binding protein 1) expression helps to predict the prognosis of hepatocellular carcinoma (HCC) in patients. It can control the T-cell anergy by improving the degradation of the E3 ligase gene related to anergy in lymphocytes (GRAIL).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Expression of OTUB1 in hepatocellular carcinoma and its effects on HCC cell migration and invasion
Ni Q, et al.
Acta biochimica et biophysica Sinica, 49(8) (2017)
Colon cancer bears overexpression of OTUB1
Liu X, et al.
Pathology Research and Practice, 210(11) (2014)
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination
Baietti MF, et al.
EMBO Molecular Medicine, 8(3) (2016)
Qiong Wu et al.
The Journal of biological chemistry, 296, 100466-100466 (2021-03-01)
DNA mismatch repair (MMR) maintains genome stability primarily by correcting replication errors. MMR deficiency can lead to cancer development and bolsters cancer cell resistance to chemotherapy. However, recent studies have shown that checkpoint blockade therapy is effective in MMR-deficient cancers

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