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GW21070

Sigma-Aldrich

Anti-CXCL9 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Small inducible cytokine B9

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21070

technique(s)

western blot: suitable

NCBI accession no.

NP_002407.1

UniProt accession no.

Q07325

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CXCL9(4283)

General description

CXCL9 (chemokine (C-X-C motif) ligand 9) is a ligand for chemokine (C-X-C motif) receptor 3 (CXCR3), which is inducible by interferon-γ. It is expressed on CD4+ Th1 cells and CD8+ cytotoxic T cells. It is also secreted by neutrophils and macrophages. It acts as a chemoattractant for activated T-lymphocytes.

Immunogen

Immunogen Sequence: GI # 4505187, sequence 21-64
Recombinant small inducible cytokine B9

Application

Anti-CXCL9 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Chemokine (C-X-C motif) ligand 9 (CXCL9) is more abundantly expressed in tumors cells than in normal epithelium. CXCL9 is associated with tumor and aggressiveness of NPC (nasopharyngeal carcinoma) tumors and the serum level of this may be useful as a prognostic indicator. In NPC tumors, serum concentration is found to be significantly higher. CXCL9 can act as a potential therapeutic target for human CGGN (Cryoglobulinemic glomerulonephritis).

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J Kowalewska et al.
Advances in medical sciences, 58(2), 394-400 (2013-10-03)
Cryoglobulinemic glomerulonephritis (CGGN) is a type of membranoproliferative glomerulonephritis (MPGN) that develops in patients with systemic cryoglobulinemia. To date the exact pathogenesis of CGGN remains unclear. It has been suggested that macrophages may be significant contributors to the glomerular injury
Carrie L Kitko et al.
Blood, 123(5), 786-793 (2013-12-24)
There are no validated biomarkers for chronic GVHD (cGVHD). We used a protein microarray and subsequent sequential enzyme-linked immunosorbent assay to compare 17 patients with treatment-refractory de novo-onset cGVHD and 18 time-matched control patients without acute or chronic GVHD to
Li-Jen Hsin et al.
PloS one, 8(11), e80052-e80052 (2013-11-28)
The aim of this cohort study was to examine the role of the chemokine (C-X-C motif) ligand 9 (CXCL9) on nasopharyngeal carcinoma (NPC). Sera from 205 NPC patients and 231 healthy individuals, and 86 NPC tumor samples were enrolled. CXCL9

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