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F8507

Sigma-Aldrich

(±)-Fenfluramine hydrochloride

Synonym(s):

(±)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H16F3N · HCl
CAS Number:
16105-77-4
Molecular Weight:
267.72
MDL number:
MFCD00058016
UNSPSC Code:
12352200
PubChem Substance ID:
24894965
Pricing and availability is not currently available.

drug control

USDEA Schedule IV

application(s)

forensics and toxicology

SMILES string

Cl.CCNC(C)Cc1cccc(c1)C(F)(F)F

InChI

1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H

InChI key

ZXKXJHAOUFHNAS-UHFFFAOYSA-N

Gene Information

human ... HTR1D(3352) , HTR2C(3358) , SIGMAR1(10280)

Biochem/physiol Actions

Neurotoxic on prolonged administration or at high dosage; releases serotonin from axon terminals by a nonexocytotic mechanism; anorectic

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
093K1065
024K1165
112K0643
077F0787
052K1359

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Y X Wang et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1008-1016 (1999-11-24)
Fenfluramine is an indirect agonist of 5-hydroxytryptamine (5-HT) receptors that acts by evoking 5-HT release and blocking 5-HT reuptake in neuronal cells. The current study compared the antinociceptive properties of fenfluramine with those of the tricyclic antidepressants amitriptyline and desipramine
Justin N Siemian et al.
British journal of pharmacology, 175(9), 1519-1534 (2018-02-17)
Although the antinociceptive efficacies of imidazoline I2 receptor agonists have been established, the exact post-receptor mechanisms remain unknown. This study tested the hypothesis that monoaminergic transmission is critical for I2 receptor agonist-induced antinociception. von Frey filaments were used to assess
J D Roth et al.
European journal of pharmacology, 373(2-3), 127-134 (1999-07-22)
Fenfluramine + phentermine was a widely used combination for weight loss. Fenfluramine and phentermine are believed to act via serotonin and catecholamines, respectively. To what extent these drugs interact has not been well-established. We compared the anorectic efficacy of a
Marija Ilic et al.
Frontiers in pharmacology, 11, 673-673 (2020-06-09)
High-affinity monoamine transporters are targets for prescribed medications and stimulant drugs of abuse. Therefore, assessing monoamine transporter activity for candidate medications and newly-emerging drugs of abuse provides essential information for industry, academia, and public health. Radiotracer binding and uptake inhibition
Shoko Sato et al.
Biological & pharmaceutical bulletin, 35(10), 1697-1702 (2012-08-02)
We investigated whether postweaning protein malnutrition (PM) affects serotonergic systems. Mice were fed a PM diet or normal protein (control) diet from weaning (21 d of age). Twenty days later, we tested for behavioral effects of the selective serotonin (5-HT)(1A)
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