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EMU076851

Sigma-Aldrich

MISSION® esiRNA

targeting mouse Mfn2

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About This Item

UNSPSC Code:
41105324
NACRES:
NA.51

description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

GGAATACGCCAGTGAGAAGCTACAGCTCATCATCAGTTACACCGGCTCTAACTGCAGCCACCAAGTCCAGCAGGAATTGTCTGGGACATTTGCTCATCTGTGCCAGCAAGTTGACATCACCCGAGATAATCTGGAGCAGGAAATTGCTGCCATGAACAAGAAAGTCGAGGCTCTGGATTCACTTCAGAGCAGAGCCAAACTGCTCAGGAATAAAGCTGGCTGGTTGGACAGCGAACTCAACATGTTCACACACCAGTACCTGCAGCCCAGCAGATAGTGGGCAGCCAGGGCGGACCTGCACGAAGAAGAGGCAGGGCCGACCTCCCATCAGCTCTAGTCCTTGGCCGCTGCAGAGAGAAGGAAAGCACCCAGTCTTGTACCAGTTACTCCCTACCCCCTGCAGGAAGACCCCTGGCTCATACCCTAATGGAGACCAACAAGGACTGGA

Ensembl | mouse accession no.

ENSMUSG00000029020

NCBI accession no.

NP_573464

shipped in

ambient

storage temp.

−20°C

Gene Information

mouse ... MFN2(170731) , Mfn2(170731)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S Givvimani et al.
International journal of cardiology, 187, 325-333 (2015-04-05)
Mitochondria constitute 30% of cell volume and are engaged in two dynamic processes called fission and fusion, regulated by Drp-1 (dynamin related protein) and mitofusin 2 (Mfn2). Previously, we showed that Drp-1 inhibition attenuates cardiovascular dysfunction following pressure overload in
Alejandro Martorell-Riera et al.
The EMBO journal, 33(20), 2388-2407 (2014-08-26)
Mitochondrial fusion and fission is a dynamic process critical for the maintenance of mitochondrial function and cell viability. During excitotoxicity neuronal mitochondria are fragmented, but the mechanism underlying this process is poorly understood. Here, we show that Mfn2 is the

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