Skip to Content
Merck
All Photos(1)

Documents

E1257

Sigma-Aldrich

Epidermal Growth Factor from murine submaxillary gland

lyophilized powder, BioReagent, suitable for cell culture

Synonym(s):

EGF, Epidermal cell growth factor

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

CAS Number:
62229-50-9
EC Number:
263-468-7
MDL number:
MFCD01634807
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

mouse submaxillary glands

Quality Level

200

product line

BioReagent

Assay

≥98% (SDS-PAGE)

form

lyophilized powder

potency

0.02-2.0 ng/mL EC50

packaging

pkg of 0.1 mg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

UniProt accession no.

P01132

storage temp.

2-8°C

Gene Information

mouse ... Egf(13645)

Looking for similar products? Visit Product Comparison Guide

General description

Epidermal growth factor (EGF) is the member of EGF-like family of growth factors, that binds to EGF receptor. It is majorly expressed in kidney, parotid gland and salivary gland.

Application

Epidermal Growth Factor from murine submaxillary gland has been used
  • in studying its effects on the development of caustic esophageal stricture in rats
  • for preparation of MCF-10A cell line
  • for the culture of primary hair follicle stem cells from arbas cashmere goat (gHFSCs) and adhesion of hair follicles (HF)

Biochem/physiol Actions

Epidermal growth factor (EGF) blocks gastric acid and pepsin secretion and increases gastrointestinal cell proliferation. EGF stimulates proliferation and migration in bone marrow stromal cells (BMSC), that gives rise to osteoblasts, chondrocytes and adipocytes. It functions as a strong mitogenic factor for various cultured cells. Mutations in this gene is linked to hypomagnesemia. EGF plays a major role in the maintenance of hair and skin development.

Physical form

Lyophilized from 0.2 μm filtered solution in ammonium acetate buffer.

Preparation Note

Purified by gel filtration and ion-exchange chromatography.

Analysis Note

The biological activity is measured in a proliferation assay using BALB/MK cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

High-sensitivity TFA-free LC-MS for profiling histones
You J, et al.
Proteomics, 11(16), 3326-3334 (2011)
Subcellular localization of epidermal growth factor receptor in human submandibular gland
Lantini MS, et al.
Journal of Anatomy, 208(5), 595-599 (2006)
Expression of epidermal growth factor in human tissues
Kajikawa K, et al.
Virchows Archiv. A, Pathological Anatomy and Histopathology, 418(1), 27-32 (1991)
Effects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in rats
Koltuksuz U, et al.
Journal of Pediatric Surgery, 36(10), 1504-1509 (2001)
Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway
Zhang H, et al.
Biochimie, 127(21), 10-18 (2016)
View All Related Papers

Articles

Neural Stem Cell FAQs

Frequently asked questions about neural stem cells including NSC derivation, expansion and differentiation.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service