C5982
7-Chloro-4-hydroxy-2-phenyl-1,8-naphthyridine
solid
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About This Item
Empirical Formula (Hill Notation):
C14H9N2OCl
Molecular Weight:
256.69
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
form
solid
color
white
solubility
DMSO: 6 mg/mL
H2O: insoluble
SMILES string
Oc1cc(nc2nc(Cl)ccc12)-c3ccccc3
Gene Information
human ... ADORA1(134) , ADORA2A(135)
rat ... Adora3(25370)
Biochem/physiol Actions
A1 adenosine receptor antagonist.
Packaging
Store tightly sealed.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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P L Ferrarini et al.
Journal of medicinal chemistry, 43(15), 2814-2823 (2000-08-24)
A series of 1,8-naphthyridine derivatives (12-36), bearing a phenyl group in position 2 and various substituents in positions 4 and 7, were synthesized in an attempt to obtain potent, selective antagonists for the A1 adenosine receptor subtype. The compounds were
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