A3105
2-Amino-N-quinolin-8-yl-benzenesulfonamide
≥98% (HPLC), solid
Synonym(s):
QBS
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About This Item
Empirical Formula (Hill Notation):
C15H13N3O2S
CAS Number:
Molecular Weight:
299.35
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
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Assay
≥98% (HPLC)
form
solid
solubility
DMSO: soluble 22 mg/mL
H2O: insoluble
SMILES string
Nc1ccccc1S(=O)(=O)Nc2cccc3cccnc23
InChI
1S/C15H13N3O2S/c16-12-7-1-2-9-14(12)21(19,20)18-13-8-3-5-11-6-4-10-17-15(11)13/h1-10,18H,16H2
InChI key
NIOOKXAMJQVDGB-UHFFFAOYSA-N
Biochem/physiol Actions
Inhibitor of cell cycle at G2 phase; apoptosis inducer.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Yun-Hee Kim et al.
Biochemical pharmacology, 69(9), 1333-1341 (2005-04-14)
We screened a library of 11,000 small molecular weight chemicals, looking for compounds that affect cell viability. We have identified 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS) as a potent cytotoxic compound that induces cell cycle arrest and apoptosis. Treatment of Jurkat T cells with
Cíntia Tiemi Misugi Kayukawa et al.
Food chemistry, 303, 125388-125388 (2019-08-28)
Saponins are known for their bioactive and surfactant properties, showing applicability to the food, cosmetic and pharmaceutical industries. This work evaluated the saponins effects on Kluyveromyces lactis β-galactosidase activity and correlated these changes to the protein structure. Enzyme kinetic was
Minji Kang et al.
ACS applied materials & interfaces, 9(3), 2686-2692 (2016-12-30)
We report on the fabrication of an organic thin-film semiconductor formed using a blend solution of soluble ambipolar small molecules and an insulating polymer binder that exhibits vertical phase separation and uniform film formation. The semiconductor thin films are produced
Fredy Omar Beltrán-Anaya et al.
Molecular oncology, 13(4), 909-927 (2019-01-17)
Triple negative breast cancer (TNBC) represents an aggressive phenotype with poor prognosis compared with ER, PR, and HER2-positive tumors. TNBC is a heterogeneous disease, and gene expression analysis has identified seven molecular subtypes. Accumulating evidence demonstrates that long non-coding RNA
Mónica Y Herrera-Sotero et al.
Nutrition and cancer, 72(5), 768-777 (2019-08-27)
Background: Breast and prostate cancer are frequently diagnosed neoplasias in women and men around the world. The signaling of the androgen receptor (AR) influences the development of both tumors. Since therapies focused to block the receptor's activity have not been
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