Y0000119

Hydroxycarbamide

European Pharmacopoeia (EP) Reference Standard

• Synonym(s): Hydroxyurea, Hydroxycarbamide
• Linear Formula: NH₂CONHOH
• CAS Number: 127-07-1
• Molecular Weight: 76.05
• Beilstein: 1741548
• MDL number: MFCD00007943
• UNSPSC Code: 41116107
• PubChem Substance ID: 329830855
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: hydroxycarbamide
• manufacturer/tradename: EDQM
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: NC(=O)NO
• InChI: 1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
• InChI key: VSNHCAURESNICA-UHFFFAOYSA-N
• Gene Information: human ... RRM1(6240) , RRM2(6241) , RRM2B(50484)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydroxycarbamide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H340,H361
• Precautionary Statements: P201 - P308 + P313
• Hazard Classifications: Muta. 1B - Repr. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable