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R0800000

Rifampicin quinone

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Dehydrorifampicin

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About This Item

Empirical Formula (Hill Notation):
C43H56N4O12
CAS Number:
13983-13-6
Molecular Weight:
820.92
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

rifampicin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C43H56N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-51H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13+,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1

InChI key

IHHAOHNZEKYBLG-SBMPKVQQSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Rifampicin quinone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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[Use of dehydrorifampicin for interferon superinduction].
N A Askarkhodzhaev et al.
Antibiotiki, 25(11), 857-859 (1980-11-01)
P Konrad et al.
Clinical immunology and immunopathology, 46(1), 162-166 (1988-01-01)
Rifampicin as a potential immunosuppressive agent was tested in the rat. A freshly made-up solution of this labile antibiotic in a daily dosage of 20 mg/kg iv did not affect mean graft survival time in a heterotopic heart transplant model.
E B Tazulakhova et al.
Voprosy virusologii, (6)(6), 672-676 (1980-11-01)
A factor stimulating interferon production (FSIP) has been isolated from cells treated once or twice (at an interval of 6-8 hours) with poly(rI).poly(rC) followed by actinomycin D (2 microgram/ml) or dehydrorifampicin (50 microgram/ml). In a dilution 1:512 the preparation stimulated
Wei Li et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 42(12), 1292-1297 (2008-03-15)
A qualitative analysis method to identify related substances of rifampicin by correlation of spectra in chromatography was established. Standard chromatographic and spectral data obtained by high-performance liquid chromatography with diode array detection (HPLC-DAD) were developed and used in identification of
Leonardo Acuña et al.
Cells, 8(8) (2019-07-28)
: Aggregated forms of the synaptic protein α-synuclein (αS) have been proposed to operate as a molecular trigger for microglial inflammatory processes and neurodegeneration in Parkinson´s disease. Here, we used brain microglial cell cultures activated by fibrillary forms of recombinant

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