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P6148

Sigma-Aldrich

Paraformaldehyde

reagent grade, crystalline

Synonym(s):

Polyoxymethylene

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500 G
£36.70
1 KG
£63.60
5 KG
£209.00

£36.70


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500 G
£36.70
1 KG
£63.60
5 KG
£209.00

About This Item

Linear Formula:
HO(CH2O)nH
CAS Number:
Molecular Weight:
30.03 (as monomer)
MDL number:
UNSPSC Code:
12352114
PubChem Substance ID:
NACRES:
NA.25
grade:
reagent grade
vapor pressure:
<1.45 mmHg ( 25 °C)

£36.70


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grade

reagent grade

Quality Level

vapor density

1.03 (vs air)

vapor pressure

<1.45 mmHg ( 25 °C)

form

crystalline

autoignition temp.

572 °F

expl. lim.

73 %

mp

120-170 °C (lit.)

density

0.88 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

[O-]#[C+H2]

InChI

1S/CH2O/c1-2/h1H2

InChI key

WSFSSNUMVMOOMR-UHFFFAOYSA-N

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General description

Paraformaldehyde is a cross-linking fixative. It is changed to formaldehyde by heating and by adding small amount of sodium hydroxide.[1][2]

Application

Paraformaldehyde is recommended for use in the preparation of formalin fixatives for tissues or cells when the samples are to be used in florescence studies.
Paraformaldehyde has been used for fixing of cells and tissue sections during staining procedures.[3][4][5]

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Description
Pricing

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Dam. 1 - Flam. Sol. 2 - Muta. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

4.1B - Flammable solid hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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The development of 3-D, in vitro, endothelial culture models for the study of coronary artery disease.
Farcas MA et al.
BioMedical Engineering OnLine, 8, 30-30 (2009)
Molecular Plant Biology: A Practical Approach (2002)
Proliferation of bone marrow-derived cells contributes to regeneration after folic acid-induced acute tubular injury.
Fang TC, et al.
Journal of the American Society of Nephrology, 16, 1723-1723 (2005)
Ying Wang et al.
PloS one, 12(7), e0180731-e0180731 (2017-07-08)
Mutations in the immunoglobulin superfamily, member 1 gene (IGSF1/Igsf1) cause an X-linked form of central hypothyroidism. The canonical form of IGSF1 is a transmembrane glycoprotein with 12 immunoglobulin (Ig) loops. The protein is co-translationally cleaved into two sub-domains. The carboxyl-terminal
Burry RW
Immunocytochemistry: A Practical Guide for Biomedical Research (2009)

Articles

Available Fluorescent in situ hybridization (FISH) procedures, reagents and equipment.

Protocols

Cell staining can be divided into four steps: cell preparation, fixation, application of antibody, and evaluation.

Related Content

Three-dimensional (3D) printing of biological tissue is rapidly becoming an integral part of tissue engineering.

Questions

1–8 of 8 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What is the difference between formaldehyde and paraformaldehyde?

    1 answer
    1. Paraformaldehyde is the polymeric form of formaldehyde. It is a solid. Formaldehyde is a gas which when dissolved in water gives a formaldehyde solution. Commercially available formaldehyde solutions usually contain 10-15% methanol, which prevents the formaldehyde from forming the polymeric paraformaldehyde.

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  4. How to prepare solutions of Product P6148, Paraformaldehyde?

    1 answer
    1. Paraformaldehyde does not dissolve but rather can be depolymerized in solution. Depolymerized solutions can be prepared in water with heating to 55-60°C. If necessary, further addition of 1-2 drops of a sodium hydroxide solution may be required. Some protocols suggest that paraformaldehyde should be prepared in buffered solutions such as phosphate buffer or PBS at approximately pH 7.

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  5. What is the difference between formaldehyde and paraformaldehyde?

    1 answer
    1. Paraformaldehyde is the polymeric form of formaldehyde. Paraformaldehyde is a solid, and formaldehyde is a gas. Formaldehyde solutions consist of formaldehyde gas dissolved in a solvent of some kind.

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  6. What is the shelf life of Product P6148, Paraformaldehyde?

    1 answer
    1. The shelf life has not been assigned but guarantee of quality is 1 year from the time of receipt for unopened bottles stored at 2-8 °C.  We expect the product to be of good quality for at least 2 years.

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  7. How stable are Product P6148, Paraformaldehyde, solutions?

    1 answer
    1. Buffered solutions of 2-4% can be stored protected from light for 2-3 weeks at 2-8°C.

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  8. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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