MABC543

Anti-FBPase 1, clone 13A8.1 Antibody

clone 13A8.1, from mouse

• Synonym(s): Fructose-1,6-bisphosphatase 1, FBPase 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase 1, Liver FBPase
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 100
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 13A8.1, monoclonal
• species reactivity: mouse, human
• technique(s): immunohistochemistry: suitable (paraffin); western blot: suitable
• isotype: IgMκ
• NCBI accession no.: NP_000498
• UniProt accession no.: P09467
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... FBP1(2203)

Description

General description

Fructose-1, 6-bisphosphatase 1 (FBPase 1), also known as D-fructose-1, 6-bisphosphate 1-phosphohydrolase 1, and encoded by the gene name FBP1 and FBP, belongs to the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory enzyme that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations; thus, acting as a rate-limiting enzyme in gluconeogenesis. FBPase 1 has been demonstrated to play a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. FBPase 1 may be involved in modulating glycerol gluconeogenesis in liver. FBPase 1 has been studied as an important regulator of appetite and adiposity. Increased expression of FBPase 1 in liver, after nutrient excess, increases circulating satiety hormones and reduces appetite-stimulating neuropeptides. Therefore, FBPase 1 may be an important target that provides a feedback mechanism to limit weight gain. FBPase 1 is expressed mainly in pancreatic islets.

Immunogen

KLH-conjugated linear peptide corresponding to human FBPase 1.

Application

Anti-FBPase 1, clone 13A8.1 | MABC543 is an antibody against FBPase 1 for use in Western Blotting, Immunohistochemistry (Paraffin).

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FBPase 1 in human pancreas tissue.

Quality

Evaluated by Western Blotting in mouse stomach tissue lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected FBPase 1 in 10 µg of mouse stomach tissue lysate.

Target description

~36 kDa observed. Uncharacterized band(s) may appear in some lysates.

Physical form

Format: Purified

Other Notes

Concentration: Please refer to lot specific datasheet.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable