Anti-GBA, mouse monoclonal, clone 2E2, recognizes the ~60 kDa GBA in MCF-7 and HeLa cells and human breast cancer tissue. It is validated for use in ELISA, WB, ICC, and IHC on paraffin sections.
Purified mouse monoclonal antibody. Recognizes the ~60 kDa GBA protein.
Recognizes the ~60 kDa GBA protein in MCF-7 and HeLa cells and human breast cancer tissue.
Immunogen
A recombinant polypeptide corresponding to amino acids of 146-236 human GBA, expressed as a GST fusion protein
Warning
Toxicity: Regulatory Review (Z)
Analysis Note
Negative Control 293T
Positive Control MCF-7 cells, HeLa cells, Human breast cancer tissue
Other Notes
Campeau, P.M., et al. 2009. Blood114, 3181.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Human molecular genetics, 32(5), 773-789 (2022-09-22)
Sequence variants or mutations in the GBA gene are numerically the most important risk factor for Parkinson disease (PD). The GBA gene encodes for the lysosomal hydrolase enzyme, glucocerebrosidase (GCase). GBA mutations often reduce GCase activity and lead to the
Biochemical and biophysical research communications, 478(3), 1141-1146 (2016-08-20)
Mutations in LRRK2 gene cause inherited Parkinson's disease (PD) and variations around LRRK2 act as risk factor for disease. Similar to sporadic disease, LRRK2-linked cases show late onset and, typically, the presence of proteinaceous inclusions named Lewy bodies (LBs) in
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