Skip to Content
Merck
All Photos(2)

Documents

ABT131

Sigma-Aldrich

Anti-PTRF/cavin-1 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Polymerase I and transcript release factor, Cavin-1

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, rat, human

species reactivity (predicted by homology)

bovine (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI accession no.

NP_036364

UniProt accession no.

Q6NZI2

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CAVIN1(284119)

General description

Polymerase I and transcript release factor (PTRF), also known as “cavin-1,” is a small cytoplasmic protein, which interacts with caveolin-1 to assemble specialized membrane invaginations (or caveolae), in various types of cells. Caveolae house specific proteins and lipids and play a central role in cell signaling and endocytosis. PTRF may also play a role in metabolism. Mice lacking functional PTRF are affected by hyperinsulinemia and glucose intolerance. In addition, PTRF may play a role in prostate cancer.

Specificity

This antibody recognizes the Coiled Coil domain of PTRF/cavin-1.

Immunogen

KLH-conjugated linear peptide corresponding to the Coiled Coil domain of human PTRF/cavin-1.

Application

Anti-PTRF/cavin-1 Antibody detects level of PTRF/cavin-1 & has been published & validated for use in Western Blotting, IHC(P).
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected PTRF/cavin-1 in mouse cardiac tissue and mouse alveoli tissue.

Quality

Evaluated by Western Blot in human lung tissue lysate.

Western Blot Analysis: 1 mg/mL of this antibody detected PTRF/cavin-1 in 10 mg of human lung tissue lysate.

Target description

~60 kDa, ~43 kDa observed. Three isoforms at 43 kDa, 33 kDa, and 23 kDa are known to exist. This protein was observed at ~60 kDa by an independent laboratory due to post-translational modification (Hill, M. M., et al. (2008). Cell. 132(1):113-124.).

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Michael L De Ieso et al.
Frontiers in cell and developmental biology, 10, 855097-855097 (2022-04-05)
Polymorphisms in the CAV1/2 gene loci impart increased risk for primary open-angle glaucoma (POAG). CAV1 encodes caveolin-1 (Cav1), which is required for biosynthesis of plasma membrane invaginations called caveolae. Cav1 knockout mice exhibit elevated intraocular pressure (IOP) and decreased outflow
Maider Varela-Guruceaga et al.
Frontiers in physiology, 11, 565486-565486 (2020-12-17)
Repetitive complete or incomplete pharyngeal collapses are leading to chronic intermittent hypoxia (CIH), a hallmark feature of obstructive sleep apnea (OSA) syndrome responsible for many metabolic disorders. In humans, an association between OSA and insulin resistance has been found independently
Yin Shi et al.
Autophagy, 11(5), 769-784 (2015-05-07)
CAV1 (caveolin 1, caveolae protein, 22kDa) is well known as a principal scaffolding protein of caveolae, a specialized plasma membrane structure. Relatively, the caveolae-independent function of CAV1 is less studied. Autophagy is a process known to involve various membrane structures

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service