Importin subunit alpha-7, also known as Karyopherin subunit alpha-6, and encoded by the gene name KPNA6 or IPOA7, is a member of the Importin alpha family. KPNA6 is a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Randependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import
Specificity
This antibody is predicted to not cross-react with other Importin alpha family members.
Immunogen
KLH-conjugated synthetic peptide corresponding to the N-terminus of human KPNA6.
Application
Detect KPNA6 using this Anti-KPNA6 Antibody validated for use in western blotting & immunofluorescence.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected KPNA6 in HEK293 cells.
Quality
Evaluated by Western Blotting in HEK293 cell lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected KPNA6 in HEK293 cell lysate.
Target description
~63 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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