540025

Pluronic^® F-127, PROTEIN GRADE^® Detergent, 10% Solution, Sterile-Filtered

Non-ionic detergent useful for isolation of membrane proteins.

• Synonym(s): Poloxamer 407, Polyoxypropylenepolyoxyethylene Block Copolymer
• CAS Number: 9003-11-6
• MDL number: MFCD00082049
• UNSPSC Code: 12161902
• NACRES: NA.21

Properties

• Quality Level: 200
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• impurities: <200 μM aldehyde; <200 μM peroxide; 10%±1 detergent
• color: clear
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
• InChI key: RVGRUAULSDPKGF-UHFFFAOYSA-N

Description

General description

Conductivity: <50 µmhos.

Application

• The Influence of Tea Tree Oil on Antifungal Activity and Pharmaceutical Characteristics of Pluronic^® F-127 Gel Formulations with Ketoconazole.: This study investigates the effects of tea tree oil on the antifungal properties and pharmaceutical characteristics of Pluronic^® F-127 gel formulations containing ketoconazole. The research demonstrated enhanced antifungal activity and improved gel consistency, highlighting the potential of this combination for topical antifungal treatments (Wróblewska et al., 2021).


• Comprehensive and comparative studies on nanocytotoxicity of glyceryl monooleate- and phytantriol-based lipid liquid crystalline nanoparticles.: This article explores the cytotoxicity of different lipid liquid crystalline nanoparticles, including those stabilized by Pluronic F-127. The findings reveal critical insights into the safety profiles of these nanoparticles for biomedical applications (Jagielski et al., 2021).


• Co-stabilization of pioglitazone HCL nanoparticles prepared by planetary ball milling: in-vitro and in-vivo evaluation.: This research focuses on the co-stabilization of pioglitazone HCL nanoparticles using Pluronic F-127, demonstrating its effectiveness in enhancing the stability and bioavailability of the drug in both in-vitro and in-vivo settings (Alshora et al., 2020).


• Dual-responsive (pH/temperature) Pluronic F-127 hydrogel drug delivery system for textile-based transdermal therapy.: This paper presents a novel drug delivery system using Pluronic F-127 hydrogel that responds to both pH and temperature changes. The system is designed for textile-based transdermal therapy, providing controlled drug release (Chatterjee et al., 2019).


• Formulation and evaluation of novel controlled release of topical pluronic lecithin organogel of mefenamic acid.: This study formulates a controlled-release topical gel using Pluronic F-127 and lecithin to deliver mefenamic acid. The research highlights the gel′s potential for sustained drug release and enhanced therapeutic efficacy (Jhawat et al., 2016).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical form

10% aqueous solution.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

PROTEIN GRADE is a registered trademark of Merck KGaA, Darmstadt, Germany

Pluronic is a registered trademark of BASF

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable