5.04361

INCB 3284 Dimesylate

• Synonym(s): INCB 3284 Dimesylate, N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate, INCB 3284, INCB3284
• Empirical Formula (Hill Notation): C₂₆H₃₁F₃N₄O₄ · 2CH₄O₃
• CAS Number: 887401-93-6
• Molecular Weight: 648.63
• UNSPSC Code: 12352200

Properties

• Assay: ≥98% (TLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: DMSO: 12 mg/mL
• storage temp.: −20°C
• InChI: 1S/C26H31F3N4O4.2CH4O3S/c1-37-23-6-5-19(14-30-23)25(36)10-7-21(8-11-25)33-12-9-20(16-33)32-22(34)15-31-24(35)17-3-2-4-18(13-17)26(27,28)29;2*1-5(2,3)4/h2-6,13-14,20-21,36H,7-12,15-16H2,1H3,(H,31,35)(H,32,34);2*1H3,(H,2,3,4)/t20-,21?,25?;;/m1../s1
• InChI key: PNPNUHKICDECDH-SEBNIYPMSA-N

Description

General description

A potent and highly selective human CCR2 (hCCR2) antagonist (IC₅₀ = 3.7 nM, 4.7 nM, and 84 nM for monocyte chemoattractant protein-1 binding to hCCR2, chemotaxis activity, inhibition of the hERG potassium current, respectively).

Biochem/physiol Actions

Primary Target
human CCR2 (hCCR2)

Target IC₅₀: 3.7 nM, 4.7 nM, and 84 nM for different assays.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Xia, M., et al. 2009. Expert Opinion on Therapeutic Patents.19, 295.

Xue, C., et al. 2011. ACS Med. Chem. Lett.2, 450.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable