189410

Aurora Kinase Inhibitor VI, ZM447439

The Aurora Kinase Inhibitor VI, ZM447439, also referenced under CAS 331771-20-1, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): Aurora Kinase Inhibitor VI, ZM447439, 4-(4-(N-Benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline
• Empirical Formula (Hill Notation): C₂₉H₃₁N₅O₄
• CAS Number: 331771-20-1
• Molecular Weight: 513.59
• MDL number: MFCD08703125
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: O=C(C1=CC=CC=C1)NC(C=C2)=CC=C2NC3=NC=NC4=C3C=C(OC)C(OCCCN5CCOCC5)=C4
• InChI: 1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32)
• InChI key: OGNYUTNQZVRGMN-UHFFFAOYSA-N

Description

General description

A cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC₅₀ = 110 and 130 nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC₅₀ = 0.88, 1.03 and 1.79 µM for Lck, Src and MEK1, respectively, and IC₅₀ >10 µM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser¹⁰ in Xenopus cycling egg extracts at 20 µM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells.

Packaging

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Gadea, B.B. and Ruderman, J.V., 2005. Mol. Biol. Cell16, 1305.
Ditchfield, C., et al. 2003. J. Cell Biol.161, 267.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable