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Key Documents

155306-M

Millipore

AMPA Agonist, CMPA

The AMPA Agonist, CMPA controls the biological activity of AMPA. This small molecule/inhibitor is primarily used for Biochemicals applications.

Synonym(s):

AMPA Agonist, CMPA, N,Nʹ-(2,2ʹ-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide, AMPA Activator

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About This Item

Empirical Formula (Hill Notation):
C16H28N2O4S2
Molecular Weight:
376.53
UNSPSC Code:
12352200
PubChem Substance ID:
9969799

Quality Level

100

Assay

≥98% (HPLC)

form

powder
solution

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

clear almost colorless
 off-white

solubility

DMSO: 100 mg/mL

storage temp.

2-8°C

SMILES string

CC(C)S(=O)(=O)NCCC1=CC=C(C=C1)CCNS(=O)(=O)C(C)C

General description

A bisalykylsulfonamide that acts as a positive, allosteric modulator against AMPA receptors (EC50 = 45 nM and 63 nM for GluA2i and GluA2o, respectively) in a HEK 293 calcium FLIPR assay. At 10 µM, it robustly modulates receptor desensitization of both the flip (GluA2i) and flop (GluA2o) isoforms of GluA2 receptors in transfected HEK 293 cells with higher potency and efficacy than two other distinct AMPA modulators, cyclothiazide and CX614. Using a ligand bound crystal structure, it is shown to bind to the dimer interface of the extracellular ligand-binding domain of AMPA receptors, a region that partially overlaps with binding pockets for cyclothiazide and CX614.
The AMPA Agonist, CMPA controls the biological activity of AMPA. This small molecule/inhibitor is primarily used for Biochemicals applications.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Timm, D., et al. 2011. Mol. Pharm.80, 267.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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