05-486
Anti-FADD Antibody, clone 1F7
clone 1F7, Upstate®, from mouse
Synonym(s):
Anti-GIG3, Anti-IMD90, Anti-MORT1
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
1F7, monoclonal
species reactivity
mouse, human
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... FADD(8772)
mouse ... Fadd(14082)
Specificity
FADD
Immunogen
GST-tagged full-length fusion protein corresponding to human FADD
Application
Anti-FADD Antibody, clone 1F7 detects level of FADD & has been published & validated for use in WB.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Quality
routinely evaluated by immunoblot on RIPA lysates from Jurkat cells
Target description
28kDa
Linkage
Replaces: 04-1113
Physical form
Format: Purified
PBS, pH 7.2 and 50% glycerol
Protein A chromatography
Storage and Stability
2 years at -20°C
Analysis Note
Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
Pricing
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Hayley I Muendlein et al.
Science (New York, N.Y.), 367(6484), 1379-1384 (2020-03-21)
Cell death and inflammation are interdependent host responses to infection. During pyroptotic cell death, interleukin-1β (IL-1β) release occurs through caspase-1 and caspase-11-mediated gasdermin D pore formation. In vivo, responses to lipopolysaccharide (LPS) result in IL-1β secretion. In vitro, however, murine
Targeting Bcl-xL in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9.
K Kim et al.
Cell death and differentiation, 11(5), 583-587 (2004-01-31)
Simon Thompson et al.
The Journal of biological chemistry, 286(22), 19331-19339 (2011-04-12)
We have previously shown that the cell death-promoting protein Bcl-2-interacting mediator of cell death (Bim) is ubiquitinated and degraded following a neuroprotection-conferring episode of brief ischemia (preconditioning). Here, we identify the E3 ligase that ubiquitinates Bim in this model, using
Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling
McDonald, E. R., 3rd, et al
The Journal of Biological Chemistry, 276, 14939-14945 (2001)
Katerina Vlantis et al.
Immunity, 44(3), 553-567 (2016-03-18)
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflammatory bowel diseases (IBD). IEC-specific ablation of nuclear factor κB (NF-κB) essential modulator (NEMO) caused Paneth cell apoptosis and impaired antimicrobial factor
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