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890705C

Avanti

16:0-18:1 EPC (Cl Salt)

Avanti Research™ - A Croda Brand 890705C

Synonym(s):

1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

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10 MG
£154.00
25 MG
£200.00

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10 MG
£154.00
25 MG
£200.00

About This Item

Empirical Formula (Hill Notation):
C44H87NO8PCl
CAS Number:
328250-19-7
Molecular Weight:
824.59
MDL number:
MFCD22495360
UNSPSC Code:
12352211
NACRES:
NA.25

£154.00

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form

liquid

packaging

pkg of 1 × 1 mL (890705C-10mg)
pkg of 1 × 2.5 mL (890705C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 890705C

concentration

10 mg/mL (890705C-10mg)
10 mg/mL (890705C-25mg)

lipid type

transfection
cationic lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)OCC.[Cl-]

InChI key

SXRDCCSKGWBZFF-ISBKSCLYSA-M

General description

1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (16:0-18:1 EPC) is cationic lipid containing an ethyl group attached to the phosphate moiety through an ester bond and has a choline headgroup.[1]

Application

1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (chloride salt) (16:0-18:1 EPC (Cl Salt)) might be used:
  • as a cationic lipid to explore the change in organization and dynamics of a membrane-bound fluorescent probe in host membranes of varying charge[1]
  • in the preparation of small unilamellar cationic liposomes[2]
  • in a novel albumin-associated lipoplex formulation to evaluate the antitumoral efficacy of immuno-gene therapy and “suicide” gene therapy[3]

Biochem/physiol Actions

1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (16:0-18:1 EPC) is a potential transfection agent, which is also like the natural lipids.[1]

Packaging

5 mL Clear Glass Sealed Ampule (890705C-10mg)
5 mL Clear Glass Sealed Ampule (890705C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

WGK

WGK 3

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Marta Passadouro et al.
International journal of nanomedicine, 9, 3203-3217 (2014-07-26)
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and mortal cancer, characterized by a set of known mutations, invasive features, and aberrant microRNA expression that have been associated with hallmark malignant properties of PDAC. The lack of effective PDAC treatment
H Faneca et al.
Biochimica et biophysica acta, 1768(5), 1093-1102 (2007-02-14)
In the present work, we used a novel albumin-associated lipoplex formulation, containing the cationic lipid 1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (EPOPC) and cholesterol (Chol), to evaluate the antitumoral efficacy of two gene therapy strategies: immuno-gene therapy, mediated by IL-12 gene expression, and "suicide" gene
Modulation of fluorophore environment in host membranes of varying charge
Kelkar DA, et al.
Journal of Fluorescence, 13(6), 459-466 (2003)
Wei Zong et al.
Langmuir : the ACS journal of surfaces and colloids, 34(23), 6874-6886 (2018-05-20)
The success of nanoparticulate formulations in drug delivery depends on various aspects including their toxicity, internalization, and intracellular location. Vesicular assemblies consisting of phospholipids and amphiphilic block copolymers are an emerging platform, which combines the benefits from liposomes and polymersomes
Li Wang et al.
Molecular pharmaceutics, 4(4), 615-623 (2007-04-06)
To date, the primary approach to improving the transfection properties of cationic lipids has been the synthesis of new kinds of cationic amphipaths. Recently, however, it was found that combining two cationic lipid derivatives having the same head group but
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