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Sigma-Aldrich

2-Hydrazino-4-(trifluoromethyl)pyrimidine

99%

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About This Item

Empirical Formula (Hill Notation):
C5H5F3N4
CAS Number:
197305-97-8
Molecular Weight:
178.12
MDL number:
MFCD00115112
UNSPSC Code:
12352100
PubChem Substance ID:
24865523

Assay

99%

mp

99-101 °C (lit.)

SMILES string

NNc1nccc(n1)C(F)(F)F

InChI

1S/C5H5F3N4/c6-5(7,8)3-1-2-10-4(11-3)12-9/h1-2H,9H2,(H,10,11,12)

InChI key

XQCAINVUBSAUBJ-UHFFFAOYSA-N

Application

2-Hydrazino-4-(trifluoromethyl)pyrimidine may be used in the following studies:
  • As derivatization reagent for the simultaneous determination of testosterone (T) and dihydrotestosterone (DHT) in murine tissue and serum samples by liquid chromatography-electrospray ionization-tandem mass spectrometry.
  • Synthesis of organohydrazide chelate complexes of rhenium and technetium, having a metal-nitrogen-nitrogen linkage.
  • Preparation of 1-(4-methoxyphenyl)ethanone [(4-trifluoromethyl)pyrimidine-2-yl]hydrazone (NAS-75).

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBT6490
BCBK6568V
BCBJ5127V
1447826V
BCBD9723V

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Jukkarin Srivilai et al.
Steroids, 116, 67-75 (2016-10-31)
Steroid 5α-reductase (S5αR) plays an important role in metabolizing testosterone into active androgen dihydrotestosterone (DHT) which is involved in many androgen dependent disorders, such as androgenic alopecia, benign prostatic hyperplasia and acne. The method for screening for S5αR inhibition is
The synthesis and characterization of technetium and rhenium hydrazinopyrimidine chelate complexes.
Hirsch-Kuchma M, et al.
J. Chem. Soc., Dalton Trans., 18, 3185-3188 (1997)
Yan Weng et al.
Analytical biochemistry, 402(2), 121-128 (2010-04-07)
A novel method was established for simultaneous quantitation of testosterone (T) and dihydrotestosterone (DHT) in murine tissue and serum samples. Endogenous T and DHT, together with the internal standards 17alpha-methyl-T and 17alpha-methyl-DHT, were extracted from tissues and then derivatized by
Shailendra Kumar Sharma et al.
The Journal of biological chemistry, 278(46), 45661-45671 (2003-08-22)
The emergence of drug-resistant forms of Plasmodium falciparum emphasizes the need to develop new antimalarials. In this context, the fatty acid biosynthesis (FAS) pathway of the malarial parasite has recently received a lot of attention. Due to differences in the

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