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346071

Sigma-Aldrich

2-Chloro-4-hydroxybenzonitrile

98%

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About This Item

Linear Formula:
ClC6H3(OH)CN
CAS Number:
3336-16-1
Molecular Weight:
153.57
MDL number:
MFCD00052185
UNSPSC Code:
12352100
PubChem Substance ID:
24861370
NACRES:
NA.22

Assay

98%

mp

160 °C (dec.) (lit.)

functional group

chloro
nitrile

SMILES string

Oc1ccc(C#N)c(Cl)c1

InChI

1S/C7H4ClNO/c8-7-3-6(10)2-1-5(7)4-9/h1-3,10H

InChI key

BDDVAWDNVWLHDQ-UHFFFAOYSA-N

Application

2-Chloro-4-hydroxybenzonitrile may be used in the synthesis of 6-aminophenanthridines via Suzuki-Miyaura coupling reaction.[1] It may be used in the preparation of 5-bromo-2-chloro-4-hydroxybenzonitrile.[2]

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCD1696
MKBS0202V
MKBD8284V
MKBD8284
MKBD1613

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Min Ju Kim et al.
Bioorganic & medicinal chemistry, 19(18), 5468-5479 (2011-08-27)
Novel macrocyclic C-aryl glucoside SGLT2 inhibitors were designed and synthesized. Two different synthetic routes of macrocyclization were adopted to prepare novel ansa SGLT2 inhibitors. Among the compounds tested, [1,7]dioxacyclopentadecine macrocycles possessing methylthiophenyl at the distal ring 40 or ethoxyphenyl at
An expeditious synthesis of 6-aminophenanthridines.
Gug F, et al.
Tetrahedron Letters, 46(21), 3725-3727 (2005)

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