We describe detailed studies of peptide-sandwiched mesohemes PSMA and PSMW, which comprise two histidine (His)-containing peptides covalently attached to the propionate groups of iron mesoporphyrin II. Some of the energy produced by ligation of the His side chains to Fe
Science (New York, N.Y.), 325(5941), 764-767 (2009-08-08)
Pathogens can use DNA recombination to promote antigenic variation (Av) of surface structures to avoid immune detection. We identified a cis-acting DNA sequence near the antigenically variable pilin locus of the human pathogen, Neisseria gonorrhoeae. This 16-base pair guanine (G)-rich
Because the etiopathology of neurodegenerative diseases is tightly connected with oxidative stress, there is an increasing need to find compounds that might elicit an antioxidant and neuroprotective response in neurons. We found that nordihydroguaiaretic acid (NDGA), a powerful antioxidant from
The journal of sexual medicine, 5(2), 336-343 (2008-01-09)
Cyclic guanosine monophosphate (cGMP) levels can be regulated by heme oxygenase-1 and 2 (HO-1 and HO-2)-derived carbon monoxide (CO). Assessment of the effect of upregulating CO in rat corpora cavernosa (CC) on cavernous cGMP. Three experimental groups were studied: first
The journal of physical chemistry. B, 113(21), 7716-7724 (2009-05-05)
Binding of photosensitizers to target cells is a crucial step during the photodynamic effect. Sensitizer distribution is a good indication of whether the chemical is a good candidate for perturbing cell membrane integrity. Hence, the photophysical properties of porphyrinoid sensitizers
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