The minimum purity of this Vinblastine Sulfate product is 96%. The exact purity is lot specific and reported on the product Certificate of Analysis. Maximum limits allowable are also set for several residual solvents and related substances. Total impurities may not exceed 3%. The H2SO4 makes up 10.7% of the purified compound based on the molecular formula: C46H58N4O9 · H2SO4. Please see the link below to access a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sigma/v1377#product-documentation
V1377
Vinblastine sulfate salt
≥97% (HPLC), powder, plant alkaloid
Synonym(s):
VLB, Vincaleukoblastine sulfate salt
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About This Item
Empirical Formula (Hill Notation):
C46H58N4O9 · H2SO4
CAS Number:
Molecular Weight:
909.05
Beilstein:
3659812
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Product Name
Vinblastine sulfate salt, ≥97% (HPLC)
Quality Level
Assay
≥97% (HPLC)
form
(powder or amorphous or crystalline powder)
color
white to light yellow
mp
267 °C (dec.) (lit.)
absorption
14 at 270 nm in 0.1 M phosphate buffer at 1 mM
16.2 at 259 nm in ethanol at 1 mM
53.7 at 214 nm in ethanol at 1 mM
antibiotic activity spectrum
neoplastics
Mode of action
DNA synthesis | interferes
originator
Eli Lilly
storage temp.
2-8°C
SMILES string
OS(O)(=O)=O.[H][C@@]12CN(CCc3c([nH]c4ccccc34)[C@@](C1)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@]7([H])[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67[C@]89[H])C(=O)OC)C[C@](O)(CC)C2
InChI
1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
InChI key
KDQAABAKXDWYSZ-PNYVAJAMSA-N
Gene Information
human ... TBCC(6903) , TUBA1A(7846) , TUBA1B(10376) , TUBA1C(84790) , TUBA3C(7278) , TUBA3E(112714) , TUBA4A(7277) , TUBB(203068) , TUBB1(81027) , TUBB2A(7280) , TUBB2B(347733) , TUBB3(10381) , TUBB4A(10382) , TUBB4B(10383) , TUBB6(84617) , TUBB8(347688)
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Application
Vinblastine sulfate salt has been used:
- as a microtubule depolymerizing drug for the synchronization of human cell lines in G2/M phase[1]
- as a multidrug resistance screening substrate in human colon cancer cell line (HCT116) cell line[2]
- as an antimicrotubule agent in sub perineural glia of Drosophila brain[3]
Biochem/physiol Actions
Plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing self-association in spiral aggregates in a reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Depolymerizes microtubules. Arrests the cell cycle in G2/M-phase by blocking mitotic spindle formation. Triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. Substrate of Pgp and CYP3A4.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Muta. 2 - Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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Certificates of Analysis (COA)
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What is the composition of vinblastine sulfate salt. I mean what is the ratio of vinblastine: salt in this powder
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