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SML3335

Sigma-Aldrich

DIPQUO

≥98% (HPLC)

Synonym(s):

6,​8-​Dimethyl-​3-​(4-​phenyl-​1H-​imidazol-​5-​yl)​-2(1H)​-​quinolinone, 6,8-Dimethyl-3-(4-phenyl-1H-imidazol-5-yl)quinolin-2(1H)-one, RU 0226606

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About This Item

Empirical Formula (Hill Notation):
C20H17N3O
CAS Number:
1269365-82-3
Molecular Weight:
315.37
MDL number:
MFCD18492440
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1NC2=C(C)C=C(C)C=C2C=C1C3=C(C4=CC=CC=C4)N=CN3

Biochem/physiol Actions

DIPQUO is a potent activator of the bone marker alkaline phosphatase (ALP) that promotes osteogenesis in human MSCs and zebrafish. DIPQUO potently induces osteoblast differentiation. It promotes bone formation and regeneration in zebra fish. It appears that DIPQUO promotes activation of the β isoform of p38 MAP kinase

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-?
Cell Chemical Biology, 26 (2019)
Brandoch Cook et al.
The Journal of biological chemistry, 296, 100696-100696 (2021-04-26)
Bone fractures are common impact injuries typically resolved through natural processes of osteogenic regeneration and bone remodeling, restoring the biological and mechanical function. However, dysfunctionality in bone healing and repair often arises in the context of aging-related chronic disorders, such

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