Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

PZ0174

Sigma-Aldrich

Sonepiprazole hydrate

≥98% (HPLC)

Synonym(s):

4-[4-[2-[(1S)-Isochroman-1-yl]ethyl]piperazin-1-yl]benzenesulfonamide hydrate, PNU-101387, PNU-101387G, U-101387

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C21H27N3O3S · xH2O
CAS Number:
170858-33-0
Molecular Weight:
401.52 (anhydrous basis)
MDL number:
MFCD05662325
UNSPSC Code:
51111800
PubChem Substance ID:
329823748
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: >10 mg/mL

storage temp.

room temp

SMILES string

NS(=O)(=O)c1ccc(cc1)N2CCN(CC[C@@H]3OCCc4ccccc34)CC2

InChI

1S/C21H27N3O3S/c22-28(25,26)19-7-5-18(6-8-19)24-14-12-23(13-15-24)11-9-21-20-4-2-1-3-17(20)10-16-27-21/h1-8,21H,9-16H2,(H2,22,25,26)/t21-/m0/s1

InChI key

WNUQCGWXPNGORO-NRFANRHFSA-N

Biochem/physiol Actions

Sonepiprazole (U-101387) is a selective D4 dopamine antagonist. Ki = 10 nM for the dopamine D4.2 receptor.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Mark H Corrigan et al.
Biological psychiatry, 55(5), 445-451 (2004-03-17)
Selective localization of dopamine D(4) receptors in the prefrontal cortex and preferential affinity of clozapine for the dopamine D(4) receptor over the D(2) receptor led to the hypothesis that the superior efficacy of clozapine may be mediated via blockade of
K Noda-Saita et al.
Biochemical and biophysical research communications, 255(2), 367-370 (1999-03-02)
Dopamine D4-like binding sites are abundant in human cerebral cortex as detected by [3H]nemonapride. The extremely low density of D4 mRNA in human cerebral cortex is inconsistent with the high amount of D4-like binding sites. To investigate the nature of
R S Mansbach et al.
Psychopharmacology, 135(2), 194-200 (1998-03-13)
Recent evidence suggests that the dopamine D4 receptor may play a role in schizophrenia, and that the atypical properties of the antipsychotic clozapine may be attributable in part to its antagonistic actions at this receptor. In the present study, clozapine
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.
R E TenBrink et al.
Journal of medicinal chemistry, 39(13), 2435-2437 (1996-06-21)
Peter Hertel et al.
European journal of pharmacology, 573(1-3), 148-160 (2007-08-11)
The present study describes the pharmacological profile of the putative antipsychotic drug Lu 35-138 ((+)-(S)-3-{1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-3,6-dihydro-2H-pyridin-4-yl}-6-chloro-1H-indole). The in vitro receptor profile of Lu 35-138 revealed high affinity (K(i)=5 nM) and competitive antagonism (K(b)=8 nM) at dopamine D(4) receptors combined with potent
View All Related Papers

Articles

Dopamine Receptors

We offer many products related to dopamine receptors for your research needs.

Dopamine Receptors

We offer many products related to dopamine receptors for your research needs.

Dopamine Receptors

We offer many products related to dopamine receptors for your research needs.

Dopamine Receptors

We offer many products related to dopamine receptors for your research needs.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service