H5777

(±)-Huperzine A

synthetic, ≥98% (TLC)

• Synonym(s): (±)-Selagine
• Empirical Formula (Hill Notation): C₁₅H₁₈N₂O
• CAS Number: 120786-18-7
• Molecular Weight: 242.32
• MDL number: MFCD00171439
• UNSPSC Code: 12352200
• PubChem Substance ID: 24895708
• NACRES: NA.77

Properties

• biological source: synthetic
• Assay: ≥98% (TLC)
• form: powder
• solubility: methanol: 10 mg/mL, clear, colorless
• storage temp.: 2-8°C
• SMILES string: C\C=C1/C2CC3=C(C=CC(=O)N3)C1(N)CC(C)=C2
• InChI: 1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+
• InChI key: ZRJBHWIHUMBLCN-QDEBKDIKSA-N
• Gene Information: human ... BCHE(590) ; rat ... Ache(83817)

Description

General description

Huperzine A is an alkaloid derived from Chinese club moss Huperzia serrata.

Application

(±)-Huperzine A has been used in anti-acetylcholinesterase bioautographic assay.

Biochem/physiol Actions

Huperzine A is an effective acetylcholinesterase inhibitor and can cross the blood-brain barrier. Huperzine A is known to prevent cognitive defects, glutamate-induced nerve cell death.It is recognized for its use in the treatment of Alzheimer′s disease and organophosphate poisoning.

Chem/Phys Resistance

Acetylcholinesterase inhibitor.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301 + H311 + H331,H315,H319,H335
• Precautionary Statements: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves