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Key Documents

F6557

Sigma-Aldrich

FYN A, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

MGC45350, SLK, SYN

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

product line

PRECISIO® Kinase

Assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

141-195 nmol/min·mg

mol wt

~85 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... FYN(2534)

General description

FYN proto-oncogene is a member of the Src family of tyrosine kinases, and has a molecular weight of 59kDa. Post-synthesis this protein is N-myristoylated on cytoplasmic polysomes. It is palmitoylated after it has been targeted to the cell membrane. This protein can also be acylated twice, which leads to its clustering into microdomains in the caveolae-like membrane.

Biochem/physiol Actions

FYN proto-oncogene interacts with multiple signaling molecules, and is involved in T-cell receptor (TCR) signaling, brain function control, along with the control of adhesion-mediated signaling. It might have potential as a target for autoimmune disorders and alcohol addiction. It is also implicated in melanoma tumorigenes in a immunoglobulin (Ig)E-mediated manner. In mesenchymal stem cells, it controls RhoA and adipogenesis, through its interaction with mTORC2 (mammalian target of rapamycin complex 2).

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Guillermina Yanek Jiménez-Andrade et al.
Journal of hematology & oncology, 6, 56-56 (2013-08-07)
High concentrations of plasmatic IgE have been related to distinct systemic inflammatory conditions that frequently predispose individuals to hypersensitivity reactions. Although effects of IgE have been suggested to relay on the low-intensity activation of distinct effector elements of the immune
William R Thompson et al.
Stem cells (Dayton, Ohio), 31(11), 2528-2537 (2013-07-10)
Mechanical strain provides an anti-adipogenic, pro-osteogenic stimulus to mesenchymal stem cells (MSC) through generating intracellular signals and via cytoskeletal restructuring. Recently, mTORC2 has been shown to be a novel mechanical target critical for the anti-adipogenic signal leading to preservation of
M D Resh
The international journal of biochemistry & cell biology, 30(11), 1159-1162 (1998-12-05)
Fyn is a 59 kDa member of the Src family of tyrosine kinases. The protein is synthesized and N-myristoylated on cytosolic polysomes and then rapidly targeted to the plasma membrane, where it is palmitoylated. Dually acylated Fyn clusters in caveolae-like
Kechen Ban et al.
Blood, 111(5), 2904-2908 (2008-01-09)
Chronic myelogenous leukemia (CML) invariably progresses to blast crisis, which represents the most proliferative phase of the disease. The BCR-ABL1 oncogene stimulates growth and survival pathways by phosphorylating numerous substrates, including various Src family members. Here we describe up-regulation, in
Hyang-Sook Hoe et al.
The Journal of biological chemistry, 283(10), 6288-6299 (2007-12-20)
Dab1 is an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2), increases their levels on the cell surface, and increases their cleavage by alpha-secretases. To investigate the mechanism underlying these alterations in processing

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