Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

80198

Sigma-Aldrich

Methoxatin disodium salt

≥97.0% (HPLC)

Synonym(s):

PQQ, Pyrrolo-quinoline-quinone disodium salt

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C14H4N2Na2O8
CAS Number:
122628-50-6
Molecular Weight:
374.17
MDL number:
MFCD00151711
UNSPSC Code:
12352005
PubChem Substance ID:
329768729
NACRES:
NA.79
Pricing and availability is not currently available.

biological source

fermentation/recombinant

Quality Level

100

Assay

≥97.0% (HPLC)

form

powder

color

red-brown to deep orange
 red-brown to deep red-brown

storage temp.

2-8°C

SMILES string

OC(=O)c1cc(nc2C(=O)C(=O)c3cc([nH]c3-c12)C(=O)O[Na])C(=O)O[Na]

InChI

1S/C14H6N2O8.2Na/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18;;/h1-2,15H,(H,19,20)(H,21,22)(H,23,24);;/q;2*+1/p-2

InChI key

UFVBOGYDCJNLPM-UHFFFAOYSA-L

General description

Methoxatin/pyrroloquinoline quinone (PQQ) is mostly seen in plants, few bacteria and single cell eukaryotes, like yeast.[1] It is mainly obtained from methylotrophic bacteria. PQQ may also present in the tissues of mammals.[2]

Application


  • Safety assessment of a novel, dietary pyrroloquinoline quinone disodium salt (mnemoPQQ): This study investigates the safety profile of Methoxatin disodium salt, which has implications for its application in assay development for clinical and diagnostic purposes. Specifically, it addresses the compound′s use in dietary supplements and potential crossover into clinical assays where safety and toxicity are paramount (Shiojima et al., 2022).


Biochem/physiol Actions

In bacteria, pyrroloquinoline quinone (PQQ) is used as a redox cycling cofactor.[2] It acts as a cofactor[2] (prosthetic group) for enzyme-catalyzed redox reactions of glucose and methanol dehydrogenase(s). PQQ is used in liposomes to establish a simple homogeneous assay for the detection of membrane permeabilization by antimicrobial peptides and synthetic copolymers.[3] In bovine plasma amine oxidase, methoxatin may acts as the cofactor.[4]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCJ8330
BCCD8905
BCCB1989
BCBR8576V
BCBQ2450V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Lingbo Kong et al.
PloS one, 8(4), e61013-e61013 (2013-04-25)
The effects of pyrroloquinoline quinine (PQQ) on RANKL-induced osteoclast differentiation and on wear particle-induced osteolysis were examined in this study. PQQ inhibited RANKL-mediated osteoclast differentiation in bone marrow macrophages (BMMs) in a dose-dependent manner without any evidence of cytotoxicity. The
Mohamed Alburaki et al.
PloS one, 10(5), e0125790-e0125790 (2015-05-21)
Thirty-two honeybee (Apis mellifera) colonies were studied in order to detect and measure potential in vivo effects of neonicotinoid pesticides used in cornfields (Zea mays spp) on honeybee health. Honeybee colonies were randomly split on four different agricultural cornfield areas
Pyrroloquinoline Quinone: Its Profile, Effects on the Liver and Implications for Health and Disease Prevention
Dietary Interventions in Liver Disease, 157-173 (2019)
Chee-Hoe Ng et al.
Neurobiology of aging, 55, 33-37 (2017-04-14)
Despite intensive research, the etiology of Parkinson's disease (PD) remains poorly understood and the disease remains incurable. However, compelling evidence gathered over decades of research strongly support a role for mitochondrial dysfunction in PD pathogenesis. Related to this, PGC-1α, a
Vitamins
Clinical biochemistry of domestic animals, 695-730 (2008)
View All Related Papers

Questions

1–3 of 3 Questions  

  1. Can this be used as a Certified Standard or Secondary Standard?

    1 answer

    1. No, this product is not intended for used as an analytical standard. The material has not been tested against any compendial or agency standard.

      Helpful?

  2. What solvents can be used to reconstitute Product 80198, Methoxatin?

    1 answer

    1. Product 80198, Methoxatin disodium salt is soluble in water up to 3 mg/ml. The following reference by Zimmerman, L.B. et al., Analytical Biochemistry, 411 (2), 194-199 (2011) has solubilized the product in 250 μM in HEPES buffer (20 mM, pH 7.0, 290 mOsmol/kg).

      Helpful?

  3. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service