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30906

Sigma-Aldrich

Castor Oil, Ethoxylated

Synonym(s):

Cremophor® ELP, ELP, PEG-35 castor oil, Polyoxyl-35 castor oil

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12161900
NACRES:
NA.25

description

non-ionic

Quality Level

form

paste

impurities

alkalinity, complies
≤ acetic acid (≤0.5 g/100g (%) verfied on random samples only)
≤0.1% oleic acid
≤0.1% palmitic acid
≤0.2% sulfated ash (verfied on random samples only)
≤0.20% ricinoleic acid
≤0.5% water
≤1 ppm ethylene oxide (verfied on random samples only)
≤1.0% free fatty acids
≤10 ppm dioxan (verfied on random samples only)
≤10 ppm heavy metals (verfied on random samples only)
≤620 ppm diethylene glycol (verfied on random samples only)
≤620 ppm ethylene glycol (verfied on random samples only)

ign. residue

≤0.2%

pH

5.0-7.0 (1 g/10 mL in H2O)

viscosity

600-750 mPa.s(25 °C)

acid value

≤2.0 mg KOH/g

hydroxyl value

65‑78 mg KOH/g

iodine value

25‑35 g/100g

saponification value

65‑70 mg KOH/g

cation traces

K: ≤15 ppm

InChI

1S/C4H7Cl2NO2/c5-1-3(2-6)9-4(7)8/h3H,1-2H2,(H2,7,8)

InChI key

JMNCUXPHXKHBPY-UHFFFAOYSA-N

Application

Castor Oil, Ethoxylated is used to emulsify and solubilize oils and other water-insoluble substances. Similar to Castor Oil, Ethoxylated but with lower water content and differences in viscosity.

Analysis Note

relative density D (25/25) 1.05-1.06

Legal Information

Cremophor is a registered trademark of BASF SE

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

494.6 °F - Not applicable

Flash Point(C)

257 °C - Not applicable


Certificates of Analysis (COA)

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Kumiko Ueda et al.
Journal of drug targeting, 11(1), 37-43 (2003-07-11)
Lipid emulsions with particle sizes of 190-270 nm were prepared with soybean oil (SO) and a series of hydrogenated castor oils (HCOs) with various oxyethylene numbers, and the effect of oxyethylene numbers of HCOs on the pharmacokinetics of menatetrenone incorporated
Ravouru Nagaraju et al.
Current drug discovery technologies, 6(4), 299-305 (2009-12-23)
The core-in-cup matrix tablets of Metoprolol succinate were prepared by wet granulation technique. Of all the investigated formulations, the optimized formulation of MS-09 followed zero-order kinetics of drug release. Trail on MS-09 was formulated using 7.5% hydrogenated castor-oil (HCO) and
Hideki Ichikawa et al.
Current drug delivery, 4(2), 131-140 (2007-04-26)
The effects of the formulation and particle composition of gadolinium (Gd)-containing lipid nanoemulsion (Gd-nanoLE) on the biodistribution of Gd after its intravenous (IV) injection in D(1)-179 melanoma-bearing hamsters were evaluated for its application in cancer neutron-capture therapy. Gd-nanoLEs whose particles
Enas A Mahmoud et al.
AAPS PharmSciTech, 10(1), 183-192 (2009-02-25)
The purpose of this study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form emphasizing the excipients' effect on the development of a new dosage form. Systems composed of HCO-40, Transcutol HP
Siva Narayanan et al.
Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society, 32(3), 163-170 (2005-06-03)
This study compared clinical outcomes and nursing labor costs associated with (a) balsam Peru, hydrogenated castor oil, and trypsin (BCT) ointment; (b) BCT + Other; and (c) Other treatments in 2014 wound episodes occurring in 861 patients (mean 2.34 wounds/patient).

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