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Key Documents

D2963000

Doxapram hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Doxapram hydrochloride monohydrate, 1-Ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone monohydrochloride monohydrate

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About This Item

Empirical Formula (Hill Notation):
C24H30N2O2 · HCl · H2O
CAS Number:
7081-53-0
Molecular Weight:
432.98
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

doxapram

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

InChI

1S/C24H30N2O2.ClH.H2O/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21;;/h3-12,22H,2,13-19H2,1H3;1H;1H2

InChI key

ZOMBFZRWMLIDPX-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Doxapram hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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Dennis J Murphy et al.
Journal of pharmacological and toxicological methods, 62(1), 47-53 (2010-05-04)
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American journal of veterinary research, 68(12), 1407-1416 (2007-12-07)
To determine and compare the effects of caffeine and doxapram on cardiorespiratory variables in foals during isoflurane-induced respiratory acidosis. 6 clinically normal foals (1 to 3 days old). At intervals of > or = 24 hours, foals received each of
Daihua Yu et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 57(9), 843-848 (2010-06-08)
The study was designed to determine the incidence of postoperative agitation following general anesthesia in 2,000 adult patients and to examine the associated risk factors. The study enrolled 2,000 adults who were scheduled for surgery under general anesthesia in a
J J P Goldring et al.
British journal of hospital medicine (London, England : 2005), 69(8), 444-449 (2008-09-12)
Acute-on-chronic respiratory failure is becoming an increasingly common medical emergency, mostly as a result of exacerbations of chronic obstructive pulmonary disease. It is associated with high mortality rates and so practising the best evidence-based management is vital.
A Greenough et al.
Archives of disease in childhood. Fetal and neonatal edition, 93(3), F242-F245 (2007-11-17)
Randomised trials have demonstrated that ventilation techniques which support every spontaneous breath are the most efficacious weaning modes. Nasal continuous positive airway pressure after extubation reduces the likelihood of incidents leading to the need for reintubation in very low birthweight
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