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D2954000

Dobutamine hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H23NO3 · HCl
CAS Number:
49745-95-1
Molecular Weight:
337.84
MDL number:
MFCD00153795
UNSPSC Code:
41116107
PubChem Substance ID:
329798764
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

dobutamine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl[H].CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2

InChI

1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H

InChI key

BQKADKWNRWCIJL-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153) , ADRB2(154)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dobutamine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332,H361fd

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Jamshid Shirani et al.
The American journal of cardiology, 112(9), 1293-1297 (2013-07-23)
In patients with obstructive coronary artery disease, electrocardiographic (ECG) ST-segment elevation (STE) is frequently seen during dobutamine stress echocardiography (DSE) in leads overlying previous transmural left ventricular (LV) myocardial infarction. The mechanism of occasional STE during DSE in LV region
Marie-Annick Clavel et al.
JACC. Cardiovascular imaging, 6(2), 175-183 (2013-03-16)
The objective of this study was to examine the value of stress-echocardiography in patients with paradoxical low-flow, low-gradient (PLFLG) aortic stenosis (AS). The projected aortic valve area (AVAProj) at a normal flow rate was calculated in 55 patients with PLFLG
Heiner Latus et al.
The Journal of thoracic and cardiovascular surgery, 146(6), 1366-1372 (2013-03-20)
Right ventricular-pulmonary arterial coupling is an important determinant in the development of right ventricular failure. The purpose of our study was to assess right ventricular-pulmonary arterial coupling in children and adolescents with dilatation of the right ventricle after repair of
Willem J de Lange et al.
The Journal of general physiology, 141(1), 73-84 (2013-01-02)
Hypertrophic cardiomyopathy (HCM) caused by mutations in cardiac myosin-binding protein-C (cMyBP-C) is a heterogenous disease in which the phenotypic presentation is influenced by genetic, environmental, and developmental factors. Though mouse models have been used extensively to study the contractile effects
Shin Lin et al.
Journal of the American Heart Association, 2(2), e000097-e000097 (2013-04-18)
Patients with a myocardial bridge (MB) and no significant obstructive coronary artery disease (CAD) may experience angina presumably from ischemia, but noninvasive assessment has been limited and the underlying mechanism poorly understood. This study seeks to correlate a novel exercise
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