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Assay
98%
mp
200-202 °C (lit.)
SMILES string
Oc1ccnc2ccccc12
InChI
1S/C9H7NO/c11-9-5-6-10-8-4-2-1-3-7(8)9/h1-6H,(H,10,11)
InChI key
PMZDQRJGMBOQBF-UHFFFAOYSA-N
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General description
4-Quinolinol (4-quinolone) is a quinolone compound which forms the core moiety of antibacterials such as norfloxacin, nalidixic acid, ciprofloxacin and cinoxacin.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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In this communication, we report the synthesis and cholinesterase (ChE)/monoamine oxidase (MAO) inhibition of 19 quinolinones (QN1-19) and 13 dihydroquinolinones (DQN1-13) designed as potential multitarget small molecules (MSM) for Alzheimer's disease therapy. Contrary to our expectations, none of them showed
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Juvenile delinquency is related to several biological factors, yet very few vulnerability biomarkers have been identified. Previous data suggest that the enzyme monoamine oxidase B (MAO-B) influences several personality traits linked to the propensity to engage in delinquent behavior. Building
Farmaco (Societa chimica italiana : 1989), 53(8-9), 611-616 (1999-03-19)
A new sensitive, rapid and accurate spectrofluorimetric method, suitable for the determination of micromolar concentrations of iron(III) in bovine liver, using 4-hydroxyquinoline (4-HQ) in an alkaline medium (KOH 2.0 x 10(-2) mol/l) as fluorescent agent, is described. The fluorescence intensity
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European journal of medicinal chemistry, 45(12), 5817-5826 (2010-10-23)
Two multivariate studies, a PCA-SAR and a PLS-QSAR, of 3-aryl-4-hydroxyquinolin-2(1H)-one derivatives described as type I fatty acid synthase (FAS) inhibitors, are presented in this work. The variable selection was performed with the Fisher's weight and Ordered Predictors Selection (OPS) algorithm
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