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Sigma-Aldrich

Chromone-3-carboxylic acid

97%

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About This Item

Empirical Formula (Hill Notation):
C10H6O4
CAS Number:
Molecular Weight:
190.15
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

97%

mp

202-205 °C (lit.)

SMILES string

OC(=O)C1=COc2ccccc2C1=O

InChI

1S/C10H6O4/c11-9-6-3-1-2-4-8(6)14-5-7(9)10(12)13/h1-5H,(H,12,13)

InChI key

PCIITXGDSHXTSN-UHFFFAOYSA-N

Gene Information

human ... PTPN1(5770)

General description

Chromone-3-carboxylic acid is a chromone derivative. Its potential as an antioxidant in charge transfer (CT) processes has been assessed by surface-enhanced Raman scattering (SERS) analysis of chromone 3-carboxylic acid adsorbed on silver colloids.

Application

Chromone-3-carboxylic acid may be used in the preparation of:
  • chromane-2,4-diones
  • chromone-3-carboxamides
  • 5-(2-hydroxyphenyl)isoxazole
  • chromone-2-carboxamides
  • chromone-2-carboxamido-3-esters

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chromone-3-carboxylic acid as a potential electron scavenger: a surface-enhanced Raman scattering study.
Machado NFL, et al.
Physical Chemistry Chemical Physics, 13(3), 1012-1018 (2011)
Conjugate addition of isocyanides to chromone 3-carboxylic acid: an efficient one-pot synthesis of chroman-4-one 2-carboxamides.
Neo AG, et al.
Organic & Biomolecular Chemistry, 10(17), 3406-3416 (2012)
Synthesis of [1] benzopyrano [3,4-d] isoxazol-4-ones from 2-substituted chromone-3-carboxylic esters. A reinvestigation of the reaction of 3-acyl-4-hydroxycoumarins with hydroxylamine. Synthesis of 4-(2-hydroxybenzoyl) isoxazol-5-ones.
Chantegrel B, et al.
The Journal of Organic Chemistry, 49(23), 4419-4424 (1984)
F Cagide et al.
Chemical communications (Cambridge, England), 51(14), 2832-2835 (2015-01-13)
The discovery of potent and selective monoamine oxidase-B inhibitors for the management of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is still a challenging endeavor. Herein, we report the discovery of two new classes of potent and selective MAO-B

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