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146358

Sigma-Aldrich

1-Ethyl-2-pyrrolidone

98%

Synonym(s):

NEP

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About This Item

Empirical Formula (Hill Notation):
C6H11NO
CAS Number:
2687-91-4
Molecular Weight:
113.16
Beilstein:
107971
EC Number:
220-250-6
MDL number:
MFCD00003199
UNSPSC Code:
12352100
PubChem Substance ID:
24848778
NACRES:
NA.22

Assay

98%

form

liquid

refractive index

n20/D 1.465 (lit.)

bp

97 °C/20 mmHg (lit.)

density

0.992 g/mL at 25 °C (lit.)

SMILES string

CCN1CCCC1=O

InChI

1S/C6H11NO/c1-2-7-5-3-4-6(7)8/h2-5H2,1H3

InChI key

ZFPGARUNNKGOBB-UHFFFAOYSA-N

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General description

1-Ethyl-2-pyrrolidone is a transdermal absorption-enhancing compound and mechanism of its effect on multilammellar liposome of stratum corneum lipid has been studied.

Application

1-Ethyl-2-pyrrolidone was used to modify coir fiber (from Cocos nucifera) by photocuring.

Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Statements

H318,H360D

Hazard Classifications

Eye Dam. 1 - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

195.8 °F - Pensky-Martens closed cup

Flash Point(C)

91 °C - Pensky-Martens closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Effect of Pretreatment with Ultraviolet Radiation on the Physicomechanical Properties of Photocured Coir (Cocos nucifera) Fiber with 1-Ethyl-2-Pyrrolidone (1-E-2-P) Monomer.
Khan MA, et al.
Polymer-Plastics Technology and Engineering, 45(4), 487-494 (2006)
Effect of penetration enhancers (pyrrolidone derivatives) on multilamellar liposomes of stratum corneum lipid: a study by UV spectroscopy and differential scanning calorimetry.
Kim C-K, et al.
International Journal of Pharmaceutics, 95(1), 43-50 (1993)
Xiaolei Zhu et al.
Aging cell, 16(5), 1073-1082 (2017-08-05)
The accumulation and deposition of beta-amyloid (Aβ) is a key neuropathological hallmark of Alzheimer's disease (AD). Histone deacetylases (HDACs) are promising therapeutic targets for the treatment of AD, while the specific HDAC isoforms associated with cognitive improvement are poorly understood.
Francisco M Pinto et al.
Reproductive biology and endocrinology : RB&E, 8, 104-104 (2010-08-28)
We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa. Freshly ejaculated semen was collected from forty-eight normozoospermic human donors. We analyzed the expression of substance P, neurokinin A, neurokinin
Małgorzata Sobocińska et al.
Amino acids, 51(8), 1201-1207 (2019-07-16)
Rat sialorphin (Gln-His-Asn-Pro-Arg) is a natural blocker of neprilysin (NEP) that belongs to the family of endogenous opioid peptide-degrading enzymes. Studies have confirmed the efficiency of sialorphin in blocking the activity of NEP, both in vitro and in vivo. It
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