109428

4-Hydroxyantipyrine

99%

• Synonym(s): 4-Hydroxy-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, NSC 174055
• Empirical Formula (Hill Notation): C₁₁H₁₂N₂O₂
• CAS Number: 1672-63-5
• Molecular Weight: 204.23
• MDL number: MFCD00003143
• UNSPSC Code: 12352100
• PubChem Substance ID: 24846917
• NACRES: NA.22

Properties

• Assay: 99%
• mp: 184-186 °C (lit.)
• SMILES string: CN1N(c2ccccc2)C(=O)C(O)=C1C
• InChI: 1S/C11H12N2O2/c1-8-10(14)11(15)13(12(8)2)9-6-4-3-5-7-9/h3-7,14H,1-2H3
• InChI key: SKVPTPMWXJSBTF-UHFFFAOYSA-N

Description

General description

4-Hydroxyantipyrine is formed during oxidative deamination of aminopyrine. It is a metabolite of antipyrine.

Application

4-Hydroxyantipyrine was used to study the relationships between the metabolism of antipyrine, hexobarbitone and theophylline in man. It was used in a study on flow injection analysis system for the characterisation of pharmaceutical compounds via combination of diode array UV, 1H NMR, FT-IR spectroscopy and time-of-flight mass spectrometry.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves