- Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes.
Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes.
Bulletin of experimental biology and medicine (2018-03-27)
S V Nikulin, M P Raigorodskaya, A A Poloznikov, G S Zakharova, U Schumacher, D Wicklein, C Stürken, K Riecken, K A Fomicheva, B Ya Alekseev, M Yu Shkurnikov
PMID29577195
RÉSUMÉ
Protein IGFBP6 plays an important role in the pathogenesis of many malignant tumors, including breast cancer. The relationship between IGFBP6 protein and the expression of genes associated with the epithelial-mesenchymal transition is studied. Gene IGFBP6 knockdown does not trigger the epithelial-mesenchymal transition in MDA-MB-231 cells, but modifies significantly the expression of many genes involved in this process. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug.