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V900480

Sigma-Aldrich

CHAPS

Vetec™, reagent grade, 96%

Synonyme(s) :

3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate

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About This Item

Formule empirique (notation de Hill):
C32H58N2O7S
Numéro CAS:
75621-03-3
Poids moléculaire :
614.88
Numéro MDL:
MFCD00012116
Code UNSPSC :
12161703
ID de substance PubChem :
329829881

Qualité

reagent grade

Description

zwitterionic

Gamme de produits

Vetec™

Pureté

96%

Poids mol.

micellar avg mol wt 6150

Nombre d'agrégation

10

CMC

6 mM (20-25°C)

Température de transition

cloud point >100 °C

Chaîne SMILES 

C[C@H](CCC(=O)NCCC[N+](C)(C)CCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)CC4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

InChI

1S/C32H58N2O7S/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41)/t21-,22?,23-,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1

Clé InChI

UMCMPZBLKLEWAF-RFCNGIAKSA-N

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Application

CHAPS is a nondenaturing zwitterionic detergent for membrane biochemistry.
Useful for solubilizing membrane proteins and breaking protein-protein interactions. CHAPS′ small micellar molecular weight (6,150) and high critical micelle concentration (6-10 mM) allow it to be removed from samples by dialysis. It is also suitable for protein solubilization for isoelectric focusing and two-dimensional electrophoresis. CHAPS is commonly used for non-denaturing (without urea) IEF and has been shown to give excellent resolution of some subcellular preparations and plant proteins. Concentrations between 2-4% (w/v) are typically used in an IEF gel.

Informations légales

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H360D

Classification des risques

Acute Tox. 4 Oral - Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Hannah R Bridges et al.
The Biochemical journal, 462(3), 475-487 (2014-07-16)
The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite evidence that inhibition of mitochondrial respiratory complex I by metformin is the primary cause of its cell-lineage-specific actions and therapeutic effects, the molecular
Bernardo S Franklin et al.
Nature immunology, 15(8), 727-737 (2014-06-24)
Microbes or danger signals trigger inflammasome sensors, which induce polymerization of the adaptor ASC and the assembly of ASC specks. ASC specks recruit and activate caspase-1, which induces maturation of the cytokine interleukin 1β (IL-1β) and pyroptotic cell death. Here
Hendrik Wesseling et al.
Journal of proteome research, 14(1), 411-421 (2014-11-05)
There is substantial interest in the N-methyl-d-aspartate (NMDA) receptor antagonist ketamine in psychiatric research because it exerts acute psychotomimetic and rapid antidepressant effects in rodents and humans. Here, we investigated proteomic changes in brain and serum after acute treatment of
Stephanie Campbell et al.
Journal of virology, 88(15), 8667-8677 (2014-05-23)
Apoptosis is a tightly regulated process that plays a crucial role in the removal of virus-infected cells, a process controlled by both pro- and antiapoptotic members of the Bcl-2 family. The proapoptotic proteins Bak and Bax are regulated by antiapoptotic
Laetitia Aerts et al.
The Journal of general virology, 96(Pt 4), 767-774 (2014-12-19)
The human metapneumovirus (HMPV) fusion (F) protein is the most immunodominant protein, yet subunit vaccines containing only this protein do not confer complete protection. The HMPV matrix (M) protein induces the maturation of antigen-presenting cells in vitro. The inclusion of
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