15020AST
Astec® CHIROBIOTIC® V2 Chiral (5 μm) HPLC Columns
L × I.D. 25 cm × 2.1 mm, HPLC Column
Synonyme(s) :
TM=["Astec"] TM=["CHIROBIOTIC"] V2 Chiral Chromatography Column
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About This Item
Code UNSPSC :
41115700
eCl@ss :
32110501
Nomenclature NACRES :
SB.52
Produits recommandés
product name
Astec® Chirobiotic® V2 Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 2.1 mm
Matériaux
stainless steel column
Agence
suitable for USP L88
Description
HPLC column
Gamme de produits
Astec®
Conditionnement
pkg of 1 ea
Fabricant/nom de marque
Astec®
Paramètres
0-45 °C temperature
241 bar pressure (3500 psi)
Technique(s)
HPLC: suitable
LC/MS: suitable
L × D.I.
25 cm × 2.1 mm
Matrice
High-purity silica gel particle platform
fully porous particle
Groupe de la matrice active
vancomycin phase
Taille des particules
5 μm
Dimension de pores
200 Å
operating pH range
3.5-7.0
Technique de séparation
chiral
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Catégories apparentées
Description générale
Neutral molecules, amides, acids, esters and amines show considerable enantioselectivity on these vancomycin-based CSPs. A wide variety of secondary and tertiary amines have been separated on the CHIROBIOTIC® V in the polar ionic mode. The CHIROBIOTIC® V has demonstrated many of the separation characteristics of protein-based stationary phases, but with exceptional stability and much higher sample capacity. Some chiral analytes have been resolved that have not been reported separated on any other chiral stationary phase. CHIROBIOTIC® V and V2 differ in their bonding chemistry the pore size of the support particle, giving them different selectivity and preparative capacity.
CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature
- Bonded phase: Vancomycin
- Operating pH range: 3.5 - 7.0
- Particle diameter: 5, 10 or 16 μm
- Pore size: 100 Å (CHIROBIOTIC® V) or 200 Å (CHIROBIOTIC® V2)
CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature
Application
- Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-threo-methylphenidate, d,l-threo-ethylphenidate and d,l-threo-ritalinic acid in rat plasma and its application to pharmacokinetic study.: This study utilizes the Astec® CHIROBIOTIC® V2 Chiral HPLC Column to develop and validate a UFLC-MS/MS method for the enantioselective determination of various methylphenidate and ritalinic acid enantiomers in rat plasma. The column′s application in pharmacokinetic studies underscores its effectiveness in biomedical research, particularly in analyzing chiral drug molecules (Zhang et al., 2016).
- New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase.: This research employs the Astec® CHIROBIOTIC® V2 Chiral HPLC Column for the chiral separation and determination of warfarin enantiomers. The study highlights the column′s utility in pharmaceutical analysis and its effectiveness in the study of chiral drug enantiomers (Malakova et al., 2009).
Informations légales
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
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Chromatography Liquid Chiral Separations
Xiao, T.L., et al.
Encyclopedia of Separation Science, 1-15 (2000)
Enantiospecific determination of dl-methylphenidate and dl-ethylphenidate in plasma by liquid chromatography?tandem mass spectrometry: Application to human ethanol interactions
Zhu, Hao-Jie, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 879 (11-12), 783-788 (2011)
Direct and indirect separations of five isomers of Brivanib Alaninate using chiral high-performance liquid chromatography
He, Brian Lingfeng, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 875 (1), 122-135 (2008)
Chiral derivatives of Butenafine and Terbinafine: synthesis and antifungal activity
Fuglseth, Erik, et al.
Tetrahedron, 65 (47), 9807-9813 (2009)
Doris Frühauf et al.
Journal of chromatography. A, 1269, 242-254 (2012-10-30)
A sub-minute enantioselective normal phase high performance liquid chromatographic (HPLC) method for the analysis of a chiral precursor molecule employed frequently in folic acid syntheses was developed, optimized and successfully validated according to ICH-guidelines. It could be shown that ultra-high
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