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W4262

Sigma-Aldrich

1400W dihydrochloride

>98%, solid

Synonyme(s) :

N-([3-(aminomethyl)phenyl]methyl)ethanimidamide dihydrochloride

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About This Item

Formule empirique (notation de Hill):
C10H15N3 · 2 HCl
Numéro CAS:
214358-33-5
Poids moléculaire :
250.17
Numéro MDL:
MFCD03428622
Code UNSPSC :
12352200
ID de substance PubChem :
24278778
Nomenclature NACRES :
NA.77

Pureté

>98%

Forme

solid

Conditions de stockage

desiccated

Auteur

GlaxoSmithKline

Conditions d'expédition

wet ice

Température de stockage

−20°C

Chaîne SMILES 

Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1

InChI

1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H

Clé InChI

WDJHSQZCZGPGAA-UHFFFAOYSA-N

Informations sur le gène

human ... NOS1(4842) , NOS2(4843) , NOS3(4846)

Application

1400W dihydrochloride has been used:
  • as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
  • as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
  • to study its efficacy on renal ischemia/ reperfusion injury in rats
  • as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation

Actions biochimiques/physiologiques

1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS).

Caractéristiques et avantages

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

1400 W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia
Shi Q, et al.
Behavioural Brain Research, 319(8), 188-199 (2017)
Simone Bido et al.
Nature communications, 12(1), 6237-6237 (2021-10-31)
Recent findings in human samples and animal models support the involvement of inflammation in the development of Parkinson's disease. Nevertheless, it is currently unknown whether microglial activation constitutes a primary event in neurodegeneration. We generated a new mouse model by
Jieyu Xu et al.
International journal of biological sciences, 16(9), 1563-1574 (2020-04-01)
The production of nitric oxide (NO) is a key feature of immunosuppressive myeloid cells, which impair T cell activation and proliferation via reversibly blocking interleukin-2 receptor signaling. NO is mainly produced from L-arginine by inducible NO synthase (iNOS). Moreover, L-arginine
L L Thomsen et al.
Cancer research, 57(15), 3300-3304 (1997-08-01)
We have investigated the effect of N-(3-(aminomethyl)benzyl)acetamidine (1400W), a novel and highly selective inhibitor for inducible NOS (iNOS), on in vivo growth of solid tumors expressing iNOS. For the EMT6 murine mammary adenocarcinoma, in which iNOS is expressed in the
Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS
Ersoz N, et al.
Renal Failure, 31(8), 704-710 (2009)
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