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UC148

6-Hydroxychlorzoxazone

Name: 6-Hydroxychlorzoxazone
Brand: SIGMA

≥98% (HPLC), solid, chlorzoxazone metabolite

Synonyme(s) :

5-Chloro-6-hydroxy-2(3H)-benzoxazolone, 5-Chloro-6-hydroxybenzoxazone

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A propos de cet article

Formule empirique (notation de Hill) :

C₇H₄ClNO₃

Numéro CAS:

1750-45-4

Poids moléculaire :

185.56

UNSPSC Code:

12161501

PubChem Substance ID:

24724641

NACRES:

NA.77

MDL number:

MFCD00143502

Assay:

≥98% (HPLC)

Form:

solid

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Propriétés

Nom du produit

6-Hydroxychlorzoxazone, ≥98% (HPLC)

Quality Segment

200

assay

≥98% (HPLC)

form

solid

color

white to pink

solubility

methanol: soluble

storage temp.

2-8°C

SMILES string

Oc1cc2OC(=O)Nc2cc1Cl

InChI

1S/C7H4ClNO3/c8-3-1-4-6(2-5(3)10)12-7(11)9-4/h1-2,10H,(H,9,11)

InChI key

AGLXDWOTVQZHIQ-UHFFFAOYSA-N

Description

Application

6-Hydroxychlorzoxazone has been used for HPLC-based metabolic assays of chlorzoxazone[1].

CYP2E1 & 1A2 metabolite of chlorzoxazone.

6-hydroxy Chlorzoxazone has been used: as a reference standard to monitor substrate depletion or 6-hydroxy chlorzoxazone formation by cytochrome P450 family 2 subfamily E member 1 (CYP2E1)in recombinant human enzyme screening. 6-Hydroxychlorzoxazone has been used for high-performance liquid chromatography (HPLC)-based metabolic assays of chlorzoxazone.[1]

Biochem/physiol Actions

6-hydroxy Chlorzoxazone is a novel metabolite of chlorzoxazone.[2] It is formed by the hydroxylation of chlorzoxazone by cytochrome P450 family 2 subfamily E member 1 (CYP2E1) enzyme. The determination of formation and clearance of 6-hydroxychlorzoxazone is used as a reliable marker of CYP2E1 metabolic activity.[2]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

6-Hydroxychlorzoxazone is soluble in methanol.

Comparer avec des articles similaires

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Cet article	C4397	SML1747	M7319
Sigma-Aldrich UC148 6-Hydroxychlorzoxazone	Sigma-Aldrich C4397 Chlorzoxazone	Sigma-Aldrich SML1747 JNJ-55511118	Sigma-Aldrich M7319 ML 10302
form solid	form powder	form powder	form solid
assay ≥98% (HPLC)	assay ≥98% (TLC)	assay ≥98% (HPLC)	assay ≥98%
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. room temp	storage temp. 2-8°C	storage temp. 2-8°C
solubility methanol: soluble	solubility DMSO: 50 mg/mL, clear	solubility DMSO: 25 mg/mL, clear	solubility DMSO: >20 mg/mL, H₂O: insoluble
color white to pink	color white to off-white	color white to beige	color white to off-white

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Lot/Batch Number

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