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T6568

Sigma-Aldrich

Tyrphostin RG 13022

≥98%

Synonyme(s) :

2-(3,4′-Dimethoxyphenyl)-1-(3″-pyridinyl)acrylonitrile

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About This Item

Formule empirique (notation de Hill):
C16H14N2O2
Numéro CAS:
136831-48-6
Poids moléculaire :
266.29
Numéro MDL:
MFCD00236444
Code UNSPSC :
12352200
ID de substance PubChem :
329826848
Nomenclature NACRES :
NA.77

Pureté

≥98%

Forme

solid

Puissance

IC50 (3 micromolar for inhibition of EGF-receptor.)

Pf

114-115 °C

Solubilité

DMSO or ethanol: soluble

Température de stockage

2-8°C

Chaîne SMILES 

COc1ccc(cc1OC)\C=C(\C#N)c2cccnc2

InChI

1S/C16H14N2O2/c1-19-15-6-5-12(9-16(15)20-2)8-14(10-17)13-4-3-7-18-11-13/h3-9,11H,1-2H3

Clé InChI

DBGZNJVTHYFQJI-UHFFFAOYSA-N

Actions biochimiques/physiologiques

Non-phenolic tyrphostin-class tyrosine kinase inhibitor.

Notes préparatoires

Tyrphostin RG 13022 is known to suppress EGF-induced cancer cell proliferation under in vitro conditions and can also inhibit the growth of tumors in nude mice.
Tyrphostin RG 13022 is soluble in DMSO and ethanol.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Consulter la Bibliothèque de documents

S Takahashi et al.
Archives of physiology and biochemistry, 110(1-2), 34-41 (2002-04-06)
Estrogen stimulates the proliferation of pituitary cells, in particular mammotrophs. The present study was designed to clarify involvement of transforming growth factor alpha (TGF-alpha) in the estrogen-induced growth of mouse pituitary cells in vitro. Anterior pituitary cells obtained from ICR
L F Gulli et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 7(2), 173-178 (1996-02-01)
A431 cells overexpress epidermal growth factor receptors (EGF-Rs) and are inhibited by EGF. We show that treatment of A431 cells with 10 nM EGF induced a 15-fold increase in EGF-R autophosphorylation, leading to inhibition of cell proliferation and morphological features
W Xian et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 6(11), 1447-1455 (1995-11-01)
The present study was designed to further investigate the role of the epidermal growth factor receptor (EGFr) in mouse skin tumor promotion by evaluating the status of the EGFr in tumor promoter-treated mouse epidermis and in mouse skin tumors. Female
T Yoneda et al.
Cancer research, 51(16), 4430-4435 (1991-08-15)
Many human tumors of epithelial origin contain cells overexpressing the epidermal growth factor (EGF) receptor, and there is convincing evidence that cancer cell growth is correlated with the loss of the normal regulation of the EGF receptor signal transduction pathway.
H L McLeod et al.
British journal of cancer, 74(11), 1714-1718 (1996-12-01)
Amplification and increased expression of many growth factor receptors, including the epidermal growth factor receptor (EGFR), has been observed in human tumours. One therapeutic strategy for overcoming EGF autocrine control of tumour growth is inhibition of EGFR protein tyrosine kinase
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