T4577

Terodiline hydrochloride

≥98% (HPLC), solid

• Synonyme(s) : Bicor, N-(1,1-Dimethylethyl)-alpha-methyl-gamma-phenylbenzenepropamine hydrochloride
• Formule empirique (notation de Hill) : C₂₀H₂₇N·HCl
• Numéro CAS: 7082-21-5
• Poids moléculaire : 317.90
• Numéro MDL: MFCD00941402
• Code UNSPSC : 12352200
• ID de substance PubChem : 329826797
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: solid
• Couleur: white to off-white
• Solubilité: DMSO: >20 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: Cl.CC(CC(c1ccccc1)c2ccccc2)NC(C)(C)C
• InChI: 1S/C20H27N.ClH/c1-16(21-20(2,3)4)15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,16,19,21H,15H2,1-4H3;1H
• Clé InChI: RNGHAJVBYQPLAZ-UHFFFAOYSA-N
• Informations sur le gène: human ... CACNA1A(773) , CACNA1B(774) , CACNA1C(775) , CACNA1D(776) , CACNA1E(777) , CACNA1F(778) , CACNA1G(8913) , CACNA1H(8912) , CACNA1I(8911) , CACNA1S(779) , CACNA2D1(781) , CACNA2D2(9254) , CACNA2D3(55799) , CACNA2D4(93589) , CACNB1(782) , CACNB2(783) , CACNB3(784) , CACNB4(785) , CACNG1(786) , CACNG2(10369) , CACNG3(10368) , CACNG4(27092) , CACNG5(27091) , CACNG6(59285) , CACNG7(59284) , CACNG8(59283) , CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

Description

Actions biochimiques/physiologiques

Terodiline hydrochloride is a non-selective calcium channel antagonist with anticholinergic and vasodilatory activity.

Terodiline is known to increase corrected QT interval (QTc) and decrease resting heart rate in elderly patients. Furthermore, terodiline hydrochloride has been linked to cardiac arrhythmias¹.

Caractéristiques et avantages

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Notes préparatoires

Terodiline hydrochloride is soluble in DMSO at a concentration that is greater than 20 mg/ml.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H319,H400
• Conseils de prudence: P273 - P301 + P312 + P330 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves