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T4143

Sigma-Aldrich

Triamterene

≥99%

Synonyme(s) :

2,4,7-Triamino-6-phenylpteridine, 6-Phenyl-2,4,7-pteridinetriamine

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About This Item

Formule empirique (notation de Hill):
C12H11N7
Numéro CAS:
396-01-0
Poids moléculaire :
253.26
Numéro CE :
206-904-3
Numéro MDL:
MFCD00006708
Code UNSPSC :
12352200
ID de substance PubChem :
24277877
Nomenclature NACRES :
NA.77

Pureté

≥99%

Solubilité

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 1.2 mg/mL
DMSO: soluble 5.4 mg/mL
H2O: insoluble

Auteur

Wellspring

Chaîne SMILES 

Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1

InChI

1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)

Clé InChI

FNYLWPVRPXGIIP-UHFFFAOYSA-N

Informations sur le gène

human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1G(6340)

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Catégories apparentées

Application

Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions2. Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay3.

Actions biochimiques/physiologiques

Weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.

Caractéristiques et avantages

This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Notes préparatoires

200 mg of triamterene is soluble in 4 ml of warm formic acid and yields a clear, yellow-green solution. Triamterene is also soluble in DMSO (5.4 mg/ml), and in 45% (w/v) aqueous 2-hydroxypropyl-β-cyclodextrin (1.2 mg/ml). However, it is insoluble in water.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H315,H319,H335

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificats d'analyse (COA)

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