SRP6465
Lipocalin-2/LCN2 human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonyme(s) :
24p3, MSFI, NGAL, Neutrophil Gelatinase-associated Lipocalin, Oncogene 24p3, Siderocalin
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About This Item
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32
Produits recommandés
Source biologique
human
Produit recombinant
expressed in HEK 293 cells
Étiquette/Marqueur
6-His tagged (C-terminus)
Pureté
≥95% (SDS-PAGE)
Forme
lyophilized
Poids mol.
calculated mol wt 22 kDa
observed mol wt 23-25 kDa (DTT reduced. Gln 21 is the predicted N-terminal.)
Conditionnement
pkg of 10 and 50 μg
Impuretés
<1 EU/μg endotoxin (LAL test)
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Informations sur le gène
human ... LCN2(3934)
Description générale
LCN2 (lipocalin 2), also known as oncogene 24p3, uterocalin, siderocalin, is a 24kDa secreted glycoprotein. It was initially identified in a mouse kidney cell culture infected with simian virus 40 (SV-40). It is a member of the transporter protein family called lipocalins which transport small, hydrophobic ligands.
Lipocalin-2 (LCN2), a secreted glycoprotein, is an adipokine. It is expressed in various cells like respiratory cells, intestinal epithelial cells, endothelial cells, renal tubular cells and cardiomyocytes. The gene LCN2 is located on human chromosome 9q34.
Actions biochimiques/physiologiques
LCN2 (lipocalin 2) functions as a biomarker for various inflammatory disorders as well as cancers. It is also thought to be involved in resistance to drug-mediated apoptosis. It interacts with matrix metalloproteinase-9 and promotes invasion, and it also facilitates tumor growth and is linked with poor prognosis. In lung adenocarcinoma this protein facilitates epithelial to mesenchymal transition (EMT), and hence, promotes metastasis and tumorigenesis, which is repealed by BRM270, an NFκB inhibitor (nuclear factor). Urine levels of LCN2 increase post-nephrotoxic and ischemic insult. In patients undergoing off pump coronary bypass surgery (OPCAB), this protein functions as an early biomarker for acute kidney injury.
Lipocalin-2 (LCN2) has been implicated in a variety of processes including cell differentiation, tumorigenesis, and apoptosis. Polymorphisms in the expression of LCN2 are associated with many cancers such as breast, colorectal, pancreatic, ovarian, gastric, thyroid, ovarian, bladder and kidney cancers.
Forme physique
Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma
Wu B, et al.
Scientific Reports (2014)
The role of neutrophil gelatinase-associated lipocalin in predicting acute kidney injury in patients undergoing off-pump coronary artery bypass graft: A pilot study.
Jain V et al
Annals of Cardiac Anaesthesia, 19(2), 225-230 (2016)
The pancreatic expression database: recent extensions and updates
Dayem Ullah AZ, et al.
Nursing New Zealand (Wellington, N.Z. : 1995) (2014)
Subhankar Chakraborty et al.
Biochimica et biophysica acta, 1826(1), 129-169 (2012-04-20)
Neutrophil gelatinase associated lipocalin (NGAL), also known as oncogene 24p3, uterocalin, siderocalin or lipocalin 2, is a 24kDa secreted glycoprotein originally purified from a culture of mouse kidney cells infected with simian virus 40 (SV-40). Subsequent investigations have revealed that
Epigenetic induction of epithelial to mesenchymal transition by LCN2 mediates metastasis and tumorigenesis, which is abrogated by NF-?B inhibitor BRM270 in a xenograft model of lung adenocarcinoma.
Mongre RK et al
International Journal of Oncology, 48(1), 84-98 (2016)
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